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Metabolic stability in Cynomolgus monkey hepatocytes assessed as intrinsic clearance at 1 uM and measured upto 120 mins by LC-MS/MS analysis
Assay data:1 Tested
SummaryPubMed Citation
Terminal half life in fasted cynomolgus monkey at 3 mg/kg, po measured for 24 hrs by LC-MS/MS analysis
Oral bioavailability in cynomolgus monkey at 20 mg/kg by LC-MS/MS analysis
Hepatic clearance in cynomolgus monkey hepatocytes
Assay data:2 Tested
Hepatic clearance in cynomolgus monkey liver microsomes
Oral bioavailability in Cynomolgus monkey at 1 mg/kg
Oral bioavailability in Cynomolgus monkey at 5 mg/kg
Half life in iv dosed Cynomolgus monkey
Volume of distribution in Cynomolgus monkey
Unbound plasma clearance in iv dosed Cynomolgus monkey
Plasma clearance in iv dosed Cynomolgus monkey
Oral bioavailability in Cynomolgous monkey at 50 mg/kg
Tmax in Cynomolgous monkey at 50 mg/kg, po
AUClast in Cynomolgous monkey at 50 mg/kg, po
Volume of distribution at steady state in Cynomolgous monkey at 1 mg/kg, iv
AUClast in Cynomolgous monkey at 1 mg/kg, iv
Clearance in Cynomolgous monkey at 1 mg/kg, iv
Oral bioavailability in Cynomolgus monkey at 5 mg/kg and measured upto 24 hrs
Half life in Cynomolgus monkey at 0.2 mg/kg, iv and measured upto 24 hrs
Volume of distribution at steady state in Cynomolgus monkey at 0.2 mg/kg, iv and measured upto 24 hrs
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