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RNAP-Inhibition Assay from Article 10.1021/acschembio.6b01133: "Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor."
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antibacterial activity against Shigella flexneri CMCC51572 assessed as prevention of visible growth by broth microdilution method
Assay data:26 Tested
SummaryPubMed Citation
Antibacterial activity against Shigella dysenteriae ATCC 49345 assessed as bacterial growth inhibition at 50 ug/ml incubated for 24 hrs relative to control
Assay data:4 Tested
Antibacterial activity against Shigella dysenteriae assessed as inhibition of bacterial growth
Assay data:1 Tested
Antibacterial activity against Shigella flexneris ATCC 12022 assessed as bacterial growth inhibition incubated for 18 hrs by microdilution method
Assay data:9 Tested
Antibacterial activity against Shigella dysenteriae
Assay data:2 Tested
Antibacterial activity against Shigella dysenteriae CICC 23829 assessed as inhibition of bacterial growth incubated for 24 hrs by broth microdilution method
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit assessed as fast off rate constant by SPR method
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit assessed as fast on rate constant by SPR method
Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay
Assay data:4 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antibacterial activity against Shigella flexneri assessed as zone of inhibition at 5 to 40 ug/ml after 18 to 24 hr by disk diffusion method relative to gatifloxacin
Assay data:5 Tested
Summary
Antibacterial activity against Shigella typhi assessed as zone of inhibition after 18 to 24 hr by disc diffusion method relative to gatifloxacin
Antibacterial activity against Shigella flexneri at 200 ug/100 uL after 24 hrs by tube broth dilution method
Antibacterial activity against Shigella flexneri at 100 ug/100 uL after 24 hrs by tube broth dilution method
Assay data:3 Tested
Antibacterial activity against Shigella sonnei ATCC 25931 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by broth microdilution method
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Antimicrobial activity against Shigella flexneri assessed as bacterial growth inhibition incubated in presence of serum for 24 hrs
Assay data:4 Active, 8 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of C-terminal 6XHis-tagged Shigella dysenteriae Stx1b (21 to 89 residues) expressed in Escherichia coli BL21 for 1 hr by ELISA assay
Antibacterial activity against Shigella dysenteriae assessed as bacterial growth inhibition
Antibacterial activity against Shigella dysenteriae assessed as bacterial growth inhibition at 12.5 ug/ml
Assay data:1 Active, 1 Tested
Antibacterial activity against Shigella flexneri CCCD S006 assessed as inhibition of bacterial growth incubated for 24 hrs by microdilution assay
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