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Items: 1 to 20 of 759

1.

Late-stage results from the probe development effort to identify antagonists of Sphingosine 1-phosphate receptor 3 (S1PR3): fluorescence-based cell-based dose response S1P1 agonists counterscreen assay

Source:
The Scripps Research Institute Molecular Screening Center
Protein Target:
Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen=CD363
3.

Summary of probe development efforts to identify agonists of Sphingosine 1-Phosphate Receptor 3 (S1P3)

Source:
The Scripps Research Institute Molecular Screening Center
Protein Targets:
Sphingosine-1-phosphate receptor 4 [Homo sapiens]; ...
Total:
5
7.

Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as probe

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
8.

Inhibition of CYP2C9 in human liver microsomes using diclofenac as probe

Source:
ChEMBL
Protein Target:
Cytochrome P450 2C9; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC9; Cholesterol 25-hydroxylase; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; S-mephenytoin 4-hydroxylase
9.

Inhibition of CYP1A2 in human liver microsomes using phenacetin as probe

Source:
ChEMBL
Protein Target:
Cytochrome P450 1A2; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3
14.

Activation of ERK1/2 in mouse BMDM assessed as phosphorylation at 10 ug/ml after 15 to 30 mins by Western blotting

Source:
ChEMBL
Protein Targets:
Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; ...
Total:
2
15.

Activation of NFkappaB p65 in mouse BMDM assessed as phosphorylation at 10 ug/ml after 15 to 30 mins by Western blotting

Source:
ChEMBL
Protein Target:
Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
16.

Activation of NFkappaB in mouse BMDM assessed as degradation of IkappaBalpha at 10 ug/ml after 15 to 30 mins by Western blotting

Source:
ChEMBL
Protein Target:
Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
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