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Luminescence counterscreen assay for p97 inhibitors: Dose response biochemical high throughput screening assay to identify inhibitors of the C522A mutant p97 ATPase.
Assay data:1 Active, 54 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of TDP-43 (unknown origin) binding to RNA
Assay data:2 Active, 2 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to TDP-43 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence
Assay data:2572 Active, 3228 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Summary of the probe development effort to identify activators of kallikrein-7 (K7) zymogen
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Summary of probe development efforts to identify inhibitors of the p97 ATPase.
Assay data:1 Active, 1 Tested
Inhibition of p97-independent reporter turnover
Assay data:12 Active, 21 Tested
Caspase 3/7 Activation in response to p97 inhibition
Assay data:5 Active, 24 Tested
Inhibition of proteasomal turnover of a p97-dependent reporter substrate in human cells - Hit Optimization Round 3
Assay data:40 Active, 2 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of proteasomal turnover of a p97-dependent reporter substrate in human cells - Hit Optimization Round 2
Assay data:27 Active, 84 Tested
p97 ATPase dose response
Assay data:20 Active, 29 Tested
Confirmation biochemical high-throughput screening assay for inhibitors of the p97 ATPase
Assay data:333 Active, 759 Tested
Luminescence counterscreen assay for p97 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of the C522A mutant p97 ATPase: synthesized compounds.
Assay data:16 Tested
Dose response biochemical high throughput screening assay for inhibitors of the p97 ATPase
Assay data:5 Active, 54 Tested
Neuroprotective activity in mouse Neuro2a cells transfected DNA (G4C2)29 C9orf 72 ALS/FTD cell model assessed as increase in cell viability at 1 ug/ml by DAPI staining based immunofluorescence analysis
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Binding affinity to C9orf72 (G4C2)2 G4 quadruplex RNA (unknown origin) assessed as change in chemical shift by one-dimensional 1H-NMR analysis
Assay data:2 Active, 2 Tested
Binding affinity to C9orf72 (G4C2)4 G4 quadruplex DNA (unknown origin) assessed as change in chemical shift at pH 6 in 25 to 45 degree C by one-dimensional 1H-NMR analysis
Assay data:3 Active, 3 Tested
Binding affinity to 5' FAM/3' TAMRA (G4C2)8 G-quadruplex DNA (unknown origin) by FRET assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen
Assay data:57 Active, 2 Activity ≤ 1 µM, 248 Tested
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput dose reponse assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence
Assay data:40 Active, 1 Activity ≤ 1 µM, 248 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
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