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Inhibition of apolipoprotein E production in human CCF-STTG1 cells at 10 uM after 24 hrs by ELISA relative to vehicle-treated control
Assay data:37 Active, 42 Tested
SummaryCompounds, ActivePubMed Citation
Increase in apoE level in CSF of rhesus monkey at 10 and 20 mg/kg, po administered for 2 weeks by apoE ELISA relative to control
Assay data:1 Tested
SummaryPubMed Citation
Antihyperlipidemic activity in apoE-deficient mouse peritoneal macrophages assessed as inhibition of acetylated LDL-induced [3H]-cholesterol ester accumulation after 24 hrs by radioscanner analysis in presence of [3H]-oleate-conjugated BSA
Assay data:1 Active, 1 Tested
Inhibition of microsomal ACAT in apoE-deficient mouse peritoneal macrophage using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after 24 hrs by TLC analysis
Antiatherosclerotic activity in apoE-deficient C57BL/6 mouse assessed as decrease in total plasma cholesterol level at 30 mg/kg/day administered through feeding measured after 80 days relative to control
Cmax in rhesus monkey at 20 mg/kg, po administered for 2 weeks
Agonist activity at LXRalpha (unknown origin) expressed in human HepG2 cells co-expressing ABCA1 promoter measured after 48 hrs by cell-based transactivation assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at LXRbeta (unknown origin) expressed in human H4 cells co-expressing ABCA1 promoter measured after 48 hrs by cell-based transactivation assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Agonist activity at GST-tagged LXRbeta-LBD (unknown origin) by LanthaScreen TR-FRET liver X receptor coactivator assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Partial agonist activity at GST-tagged LXRalpha-LBD (unknown origin) by LanthaScreen TR-FRET liver X receptor coactivator assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at GST-tagged LXRalpha-LBD (unknown origin) by LanthaScreen TR-FRET liver X receptor coactivator assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Non-competitive inhibition of human microsomal ACAT2 overexpressed in CHO cells using [14C]oleoyl-CoA as substrate assessed as formation of cholesteryl [14C]-oleate after 24 hrs
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of macrophage ACAT (unknown origin)
Inhibition of ACAT1 (unknown origin)
Inhibition of macrophage ACAT2 (unknown origin)
Inhibition of ACAT1 in human MDM assessed as inhibition of acetylated LDL-induced cholesterol ester accumulation after 1 hr by HPLC analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ACAT2 in human MDM assessed as inhibition of acetylated LDL-induced cholesterol ester accumulation after 1 hr by HPLC analysis
Antihyperlipidemic activity in human MDM assessed as inhibition of acetylated LDL-induced [3H]-cholesterol ester accumulation at 20 uM after 24 hrs by radioscanner analysis in presence of [3H]-oleate-conjugated BSA
Assay data:7 Active, 7 Tested
Inhibition of human tau (441 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in aggregation at 10 uM relative to control
Inhibition of beta secretase (unknown origin)
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