Entry - *619153 - SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, NAD+ TRANSPORTER), MEMBER 51; SLC25A51 - OMIM

 
 
* 619153

SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, NAD+ TRANSPORTER), MEMBER 51; SLC25A51


Alternative titles; symbols

MCART1


HGNC Approved Gene Symbol: SLC25A51

Cytogenetic location: 9p13.2-p13.1     Genomic coordinates (GRCh38): 9:37,877,575-37,904,127 (from NCBI)


TEXT

▼ Description

SLC25A51 belongs to the SLC25 mitochondrial transporter family (Palmieri, 2013) and is responsible for importing NAD+ into mitochondria (Luongo et al., 2020).


▼ Gene Function

Luongo et al. (2020) found that SLC25A51 was required for maintenance of mitochondrial NAD+ levels in human cells. Loss of SLC25A51 resulted in loss of mitochondrial NAD+ levels, whereas SLC25A51 overexpression increased mitochondrial NAD+ levels. Loss of SLC25A51 also impaired mitochondrial respiratory capacity and blocked uptake of NAD+ into mitochondria.


▼ Mapping

Palmieri (2013) stated that the SLC25A51 gene maps to chromosome 9p13.3-p12.

Gross (2021) mapped the SLC25A51 gene to chromosome 9p13.2-p13.1 based on an alignment of the SLC25A51 sequence (GenBank BC008500) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 1/13/2021.

  2. Luongo, T. S., Eller, J. M., Lu, M.-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E., Rabinowitz, J. D., Johnson, F. B., Johnsson, K., Ziegler, M., Cambronne, X. A., Baur, J. A. SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature 588: 174-179, 2020. [PubMed: 32906142, related citations] [Full Text]

  3. Palmieri, F. The mitochondrial transporter family SLC25: Identification, properties and physiopathology. Molec. Aspects Med. 34: 465-484, 2013. [PubMed: 23266187, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 01/13/2021
Creation Date:
Bao Lige : 01/13/2021
Edit History:
mgross : 01/13/2021

* 619153

SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, NAD+ TRANSPORTER), MEMBER 51; SLC25A51


Alternative titles; symbols

MCART1


HGNC Approved Gene Symbol: SLC25A51

Cytogenetic location: 9p13.2-p13.1     Genomic coordinates (GRCh38): 9:37,877,575-37,904,127 (from NCBI)


TEXT

Description

SLC25A51 belongs to the SLC25 mitochondrial transporter family (Palmieri, 2013) and is responsible for importing NAD+ into mitochondria (Luongo et al., 2020).


Gene Function

Luongo et al. (2020) found that SLC25A51 was required for maintenance of mitochondrial NAD+ levels in human cells. Loss of SLC25A51 resulted in loss of mitochondrial NAD+ levels, whereas SLC25A51 overexpression increased mitochondrial NAD+ levels. Loss of SLC25A51 also impaired mitochondrial respiratory capacity and blocked uptake of NAD+ into mitochondria.


Mapping

Palmieri (2013) stated that the SLC25A51 gene maps to chromosome 9p13.3-p12.

Gross (2021) mapped the SLC25A51 gene to chromosome 9p13.2-p13.1 based on an alignment of the SLC25A51 sequence (GenBank BC008500) with the genomic sequence (GRCh38).

REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 1/13/2021.

  2. Luongo, T. S., Eller, J. M., Lu, M.-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E., Rabinowitz, J. D., Johnson, F. B., Johnsson, K., Ziegler, M., Cambronne, X. A., Baur, J. A. SLC25A51 is a mammalian mitochondrial NAD+ transporter. Nature 588: 174-179, 2020. [PubMed: 32906142] [Full Text: https://doi.org/10.1038/s41586-020-2741-7]

  3. Palmieri, F. The mitochondrial transporter family SLC25: Identification, properties and physiopathology. Molec. Aspects Med. 34: 465-484, 2013. [PubMed: 23266187] [Full Text: https://doi.org/10.1016/j.mam.2012.05.005]


Contributors:
Matthew B. Gross - updated : 01/13/2021

Creation Date:
Bao Lige : 01/13/2021

Edit History:
mgross : 01/13/2021



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 16, 2024