Entry - *615056 - ANKYRIN REPEAT- AND SOCS BOX-CONTAINING PROTEIN 16; ASB16 - OMIM

 
 
* 615056

ANKYRIN REPEAT- AND SOCS BOX-CONTAINING PROTEIN 16; ASB16


HGNC Approved Gene Symbol: ASB16

Cytogenetic location: 17q21.31     Genomic coordinates (GRCh38): 17:44,170,704-44,179,084 (from NCBI)


TEXT

▼ Description

Proteins of the ASB family, such as ASB16, contain central tandem ankyrin (see 612641) repeats and a C-terminal suppressor of cytokine signaling (SOCS) box. SOCS box proteins are predicted to be involved in protein degradation by acting as a bridge between substrate proteins and E3 ubiquitin protein ligases (see 601623) (review by Kile et al., 2002).


▼ Mapping

Hartz (2013) mapped the ASB16 gene to chromosome 17q21.31 based on an alignment of the ASB16 sequence (GenBank AF403034) with the genomic sequence (GRCh37).

▼ REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/29/2013.

  2. Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., Hilton, D. J. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27: 235-241, 2002. [PubMed: 12076535, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 1/30/2013
Edit History:
mgross : 01/30/2013

* 615056

ANKYRIN REPEAT- AND SOCS BOX-CONTAINING PROTEIN 16; ASB16


HGNC Approved Gene Symbol: ASB16

Cytogenetic location: 17q21.31     Genomic coordinates (GRCh38): 17:44,170,704-44,179,084 (from NCBI)


TEXT

Description

Proteins of the ASB family, such as ASB16, contain central tandem ankyrin (see 612641) repeats and a C-terminal suppressor of cytokine signaling (SOCS) box. SOCS box proteins are predicted to be involved in protein degradation by acting as a bridge between substrate proteins and E3 ubiquitin protein ligases (see 601623) (review by Kile et al., 2002).


Mapping

Hartz (2013) mapped the ASB16 gene to chromosome 17q21.31 based on an alignment of the ASB16 sequence (GenBank AF403034) with the genomic sequence (GRCh37).

REFERENCES

  1. Hartz, P. A. Personal Communication. Baltimore, Md. 1/29/2013.

  2. Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., Hilton, D. J. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27: 235-241, 2002. [PubMed: 12076535] [Full Text: https://doi.org/10.1016/s0968-0004(02)02085-6]


Creation Date:
Patricia A. Hartz : 1/30/2013

Edit History:
mgross : 01/30/2013



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 25, 2024