Entry - *610526 - 5-PRIME-NUCLEOTIDASE, CYTOSOLIC, IB; NT5C1B - OMIM

 
 
* 610526

5-PRIME-NUCLEOTIDASE, CYTOSOLIC, IB; NT5C1B


Alternative titles; symbols

NUCLEOTIDASE, 5-PRIME, CYTOSOLIC, IB
CYTOSOLIC 5-PRIME NUCLEOTIDASE IB; CNIB; CN1B
AUTOIMMUNE INFERTILITY-RELATED PROTEIN; AIRP


HGNC Approved Gene Symbol: NT5C1B

Cytogenetic location: 2p24.2     Genomic coordinates (GRCh38): 2:18,562,871-18,589,569 (from NCBI)


TEXT

▼ Description

Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001).


▼ Cloning and Expression

Sala-Newby and Newby (2001) cloned mouse Nt5c1b, which encodes a 573-amino acid protein that shares 66% identity with pigeon and human NT5C1A (610525). Mouse Nt5c1b contains 4 putative kinase-3a sequences and 3 nucleoside monophosphate-binding type-2 sequences. By database analysis and RACE, Sala-Newby and Newby (2001) obtained a partial human NT5C1B cDNA. The partial human protein shares 87% identity with mouse Nt5c1b and 70% identity with human NT5C1A. RT-PCR analysis of human tissues revealed ubiquitous expression of NT5C1B, with highest level in testis and lowest levels in brain and skeletal muscle. Mouse Nt5c1b also showed highest expression in testis.


▼ Gene Function

Using overexpression in COS-7 cells, Sala-Newby and Newby (2001) showed that mouse Nt5c1b was activated by ADP and catalyzed adenosine formation during ATP breakdown.


▼ Mapping

By genomic sequence analysis, Sala-Newby and Newby (2001) mapped the NT5C1B gene to chromosome 2.


▼ REFERENCES

  1. Sala-Newby, G. B., Newby, A. C. Cloning of a mouse cytosolic 5-prime-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. Biochim. Biophys. Acta 1521: 12-18, 2001. [PubMed: 11690631, related citations] [Full Text]


Creation Date:
Paul J. Converse : 10/26/2006
Edit History:
mgross : 10/26/2006

* 610526

5-PRIME-NUCLEOTIDASE, CYTOSOLIC, IB; NT5C1B


Alternative titles; symbols

NUCLEOTIDASE, 5-PRIME, CYTOSOLIC, IB
CYTOSOLIC 5-PRIME NUCLEOTIDASE IB; CNIB; CN1B
AUTOIMMUNE INFERTILITY-RELATED PROTEIN; AIRP


HGNC Approved Gene Symbol: NT5C1B

Cytogenetic location: 2p24.2     Genomic coordinates (GRCh38): 2:18,562,871-18,589,569 (from NCBI)


TEXT

Description

Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001).


Cloning and Expression

Sala-Newby and Newby (2001) cloned mouse Nt5c1b, which encodes a 573-amino acid protein that shares 66% identity with pigeon and human NT5C1A (610525). Mouse Nt5c1b contains 4 putative kinase-3a sequences and 3 nucleoside monophosphate-binding type-2 sequences. By database analysis and RACE, Sala-Newby and Newby (2001) obtained a partial human NT5C1B cDNA. The partial human protein shares 87% identity with mouse Nt5c1b and 70% identity with human NT5C1A. RT-PCR analysis of human tissues revealed ubiquitous expression of NT5C1B, with highest level in testis and lowest levels in brain and skeletal muscle. Mouse Nt5c1b also showed highest expression in testis.


Gene Function

Using overexpression in COS-7 cells, Sala-Newby and Newby (2001) showed that mouse Nt5c1b was activated by ADP and catalyzed adenosine formation during ATP breakdown.


Mapping

By genomic sequence analysis, Sala-Newby and Newby (2001) mapped the NT5C1B gene to chromosome 2.


REFERENCES

  1. Sala-Newby, G. B., Newby, A. C. Cloning of a mouse cytosolic 5-prime-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. Biochim. Biophys. Acta 1521: 12-18, 2001. [PubMed: 11690631] [Full Text: https://doi.org/10.1016/s0167-4781(01)00278-0]


Creation Date:
Paul J. Converse : 10/26/2006

Edit History:
mgross : 10/26/2006



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 16, 2024