Entry - *603536 - FAR UPSTREAM ELEMENT-BINDING PROTEIN 3; FUBP3 - OMIM

 
 
* 603536

FAR UPSTREAM ELEMENT-BINDING PROTEIN 3; FUBP3


Alternative titles; symbols

FUSE-BINDING PROTEIN 3; FBP3


HGNC Approved Gene Symbol: FUBP3

Cytogenetic location: 9q34.11-q34.12     Genomic coordinates (GRCh38): 9:130,579,577-130,638,352 (from NCBI)


TEXT

▼ Cloning and Expression

Davis-Smyth et al. (1996) identified FBP2 (KHSRP; 603445) and FBP3 as proteins related to the far upstream element (FUSE)-binding protein FBP1 (FUBP1; 603444), which binds to the FUSE of the human protooncogene MYC (190080). All 3 proteins had the same general architecture, with 3 distinct domains including a central nucleic acid-binding region containing KH motifs. The FBP3 protein contains 600 amino acids. Northern blot analysis revealed that FBP3 was expressed as a 3.4-kb mRNA in all cells and tissues tested.


▼ Gene Function

Using expression studies in mammalian cells, Davis-Smyth et al. (1996) found that the C-terminal domains of the 3 FBPs are potent transcriptional activators. Each FBP bound specifically to 1 strand of the FUSE of MYC in vitro.


▼ REFERENCES

  1. Davis-Smyth, T., Duncan, R. C., Zheng, T., Michelotti, G., Levens, D. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. J. Biol. Chem. 271: 31679-31687, 1996. [PubMed: 8940189, related citations] [Full Text]


Creation Date:
Rebekah S. Rasooly : 2/16/1999
Edit History:
carol : 04/24/2014
psherman : 7/21/1999
psherman : 2/16/1999

* 603536

FAR UPSTREAM ELEMENT-BINDING PROTEIN 3; FUBP3


Alternative titles; symbols

FUSE-BINDING PROTEIN 3; FBP3


HGNC Approved Gene Symbol: FUBP3

Cytogenetic location: 9q34.11-q34.12     Genomic coordinates (GRCh38): 9:130,579,577-130,638,352 (from NCBI)


TEXT

Cloning and Expression

Davis-Smyth et al. (1996) identified FBP2 (KHSRP; 603445) and FBP3 as proteins related to the far upstream element (FUSE)-binding protein FBP1 (FUBP1; 603444), which binds to the FUSE of the human protooncogene MYC (190080). All 3 proteins had the same general architecture, with 3 distinct domains including a central nucleic acid-binding region containing KH motifs. The FBP3 protein contains 600 amino acids. Northern blot analysis revealed that FBP3 was expressed as a 3.4-kb mRNA in all cells and tissues tested.


Gene Function

Using expression studies in mammalian cells, Davis-Smyth et al. (1996) found that the C-terminal domains of the 3 FBPs are potent transcriptional activators. Each FBP bound specifically to 1 strand of the FUSE of MYC in vitro.


REFERENCES

  1. Davis-Smyth, T., Duncan, R. C., Zheng, T., Michelotti, G., Levens, D. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. J. Biol. Chem. 271: 31679-31687, 1996. [PubMed: 8940189] [Full Text: https://doi.org/10.1074/jbc.271.49.31679]


Creation Date:
Rebekah S. Rasooly : 2/16/1999

Edit History:
carol : 04/24/2014
psherman : 7/21/1999
psherman : 2/16/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 25, 2024