Alternative titles; symbols
HGNC Approved Gene Symbol: SSR2
Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,009,048-156,020,951 (from NCBI)
In order to translocate membrane or secretory proteins across the endoplasmic reticulum (ER) membrane, the signal sequence of a nascent peptide is recognized by a signal recognition particle (SRP), by which the nascent peptide associated with a ribosome can bind to the ER membrane receptor (or docking protein). The SRP is released from both the ribosome and the signal sequence; the latter lies near an integral, glycosylated ER membrane protein referred to as the signal sequence receptor (SSR). The SSR consists of 2 subunits: a 34-kD glycoprotein, alpha-SSR (SSR1; 600868), and a 22-kD glycoprotein, beta-SSR (SSR2) (summary by Chinen et al., 1995).
Chinen et al. (1995) isolated a human cDNA clone homologous to the canine beta-SSR gene. Northern blot analysis revealed ubiquitous expression of beta-SSR in all organs examined.
By FISH, Chinen et al. (1995) mapped the SSR2 gene to chromosome 1q21-q23.
Chinen, K., Sudo, K., Takahashi, E., Nakamura, Y. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). Cytogenet. Cell Genet. 70: 215-217, 1995. [PubMed: 7789174] [Full Text: https://doi.org/10.1159/000134036]