Entry - *600867 - SIGNAL SEQUENCE RECEPTOR, BETA; SSR2 - OMIM

 
 
* 600867

SIGNAL SEQUENCE RECEPTOR, BETA; SSR2


Alternative titles; symbols

TRANSLOCON-ASSOCIATED PROTEIN, BETA
TRAP-BETA


HGNC Approved Gene Symbol: SSR2

Cytogenetic location: 1q22     Genomic coordinates (GRCh38): 1:156,009,048-156,020,951 (from NCBI)


TEXT

▼ Description

In order to translocate membrane or secretory proteins across the endoplasmic reticulum (ER) membrane, the signal sequence of a nascent peptide is recognized by a signal recognition particle (SRP), by which the nascent peptide associated with a ribosome can bind to the ER membrane receptor (or docking protein). The SRP is released from both the ribosome and the signal sequence; the latter lies near an integral, glycosylated ER membrane protein referred to as the signal sequence receptor (SSR). The SSR consists of 2 subunits: a 34-kD glycoprotein, alpha-SSR (SSR1; 600868), and a 22-kD glycoprotein, beta-SSR (SSR2) (summary by Chinen et al., 1995).


▼ Cloning and Expression

Chinen et al. (1995) isolated a human cDNA clone homologous to the canine beta-SSR gene. Northern blot analysis revealed ubiquitous expression of beta-SSR in all organs examined.


▼ Mapping

By FISH, Chinen et al. (1995) mapped the SSR2 gene to chromosome 1q21-q23.


▼ REFERENCES

  1. Chinen, K., Sudo, K., Takahashi, E., Nakamura, Y. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). Cytogenet. Cell Genet. 70: 215-217, 1995. [PubMed: 7789174, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 10/16/1995
Edit History:
mgross : 06/20/2012
mgross : 10/27/2008
mark : 10/16/1995

* 600867

SIGNAL SEQUENCE RECEPTOR, BETA; SSR2


Alternative titles; symbols

TRANSLOCON-ASSOCIATED PROTEIN, BETA
TRAP-BETA


HGNC Approved Gene Symbol: SSR2

Cytogenetic location: 1q22     Genomic coordinates (GRCh38): 1:156,009,048-156,020,951 (from NCBI)


TEXT

Description

In order to translocate membrane or secretory proteins across the endoplasmic reticulum (ER) membrane, the signal sequence of a nascent peptide is recognized by a signal recognition particle (SRP), by which the nascent peptide associated with a ribosome can bind to the ER membrane receptor (or docking protein). The SRP is released from both the ribosome and the signal sequence; the latter lies near an integral, glycosylated ER membrane protein referred to as the signal sequence receptor (SSR). The SSR consists of 2 subunits: a 34-kD glycoprotein, alpha-SSR (SSR1; 600868), and a 22-kD glycoprotein, beta-SSR (SSR2) (summary by Chinen et al., 1995).


Cloning and Expression

Chinen et al. (1995) isolated a human cDNA clone homologous to the canine beta-SSR gene. Northern blot analysis revealed ubiquitous expression of beta-SSR in all organs examined.


Mapping

By FISH, Chinen et al. (1995) mapped the SSR2 gene to chromosome 1q21-q23.


REFERENCES

  1. Chinen, K., Sudo, K., Takahashi, E., Nakamura, Y. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). Cytogenet. Cell Genet. 70: 215-217, 1995. [PubMed: 7789174] [Full Text: https://doi.org/10.1159/000134036]


Creation Date:
Victor A. McKusick : 10/16/1995

Edit History:
mgross : 06/20/2012
mgross : 10/27/2008
mark : 10/16/1995



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 18, 2024