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Inflammation and the microcirculation

Author(s):
Granger, D Neil
Senchenkova, Elena
Title(s):
Inflammation and the microcirculation [electronic resource] / D. Neil Granger, Elena Senchenkova.
Series:
Integrated systems physiology : from molecule to function ; #8
Country of Publication:
United States
Publisher:
[San Rafael, CA] : Morgan & Claypool Life Sciences Publishers, c2010.
Description:
1 online resource (1 PDF file (x, 87 p. : ill.))
Language:
English
ISBN:
9781615041657 (pbk.)
9781615041664 (ebook)
Electronic Links:
http://www.ncbi.nlm.nih.gov/books/NBK53373
Summary:
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation.
MeSH:
Capillary Permeability/physiology
Cell Adhesion Molecules/physiology
Inflammation/physiopathology*
Microcirculation/physiology
Notes:
Includes bibliographical references.
Issued also in print (x, 86p. : ill.)
Title from PDF t.p. (viewed Aug. 16, 2011).
NLM ID:
101557886 [Electronic Resource]

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