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Hyperglycaemia in acute coronary syndromes : management of hyperglycaemia in people with acute coronary syndromes

Centre for Clinical Practice (National Institute for Health and Clinical Excellence (Great Britain))
Hyperglycaemia in acute coronary syndromes : management of hyperglycaemia in people with acute coronary syndromes [electronic resource] / developed by the Centre for Clinical Practice at NICE.
NICE clinical guideline ; 130
Country of Publication:
London : National Institute for Health and Clinical Excellence, c2011.
1 online resource (PDF file (232 p.)) : ill.
Electronic Links:
This guideline partially updates recommendation in "Type 1 diabetes" (NICE clinical guideline 15). Recommendation is updated for the treatment of patients with threatened or actual MI, but not stroke. This guideline covers the role of intensive insulin therapy in managing hyperglycaemia within the first 48 hours in people admitted to hospital for acute coronary syndromes (ACS). Intensive insulin therapy is defined as an intravenous infusion of insulin and glucose with or without potassium. For the purposes of this guideline, hyperglycaemia is defined as a blood glucose level above 11 mmol/litre. This definition was based on the expert opinion of the Guideline Development Group (GDG) and was agreed by consensus. ACS encompass a spectrum of unstable coronary artery disease, ranging from unstable angina to transmural myocardial infarction. All forms of ACS begin with an inflamed and complicated fatty deposit (known as an atheromatous plaque) in a blood vessel, followed by blood clots forming on the plaque. The principles behind the presentation, investigation and management of these syndromes are similar, but there are important distinctions depending on the category of ACS. Hyperglycaemia is common in people admitted to hospital with ACS. Recent studies found that approximately 65% of patients with acute myocardial infarction who were not known to have diabetes had impaired glucose regulation when given a glucose tolerance test. Hyperglycaemia at the time of admission with ACS is a powerful predictor of poorer survival and increased risk of complications while in hospital, regardless of whether or not the patient has diabetes. Despite this, hyperglycaemia remains underappreciated as a risk factor in ACS and is frequently untreated. Persistently elevated blood glucose levels during acute myocardial infarction have been shown to be associated with increased in-hospital mortality, and to be a better predictor of outcome than admission blood glucose. Management of hyperglycaemia after ACS is therefore an important clinical issue. A wide range of national guidance is available for the care of people with diabetes in hospital with relevance to ACS patients. For example the NHS Institute for Innovation and Improvement recommends that all patients with ACS and known diabetes are referred to the inpatient diabetes team.
Acute Coronary Syndrome/complications
Hyperglycemia/drug therapy*
Insulin/therapeutic use
Risk Factors
United Kingdom
Publication Type(s):
Practice Guideline
"October 2011."
Includes bibliographical references.
Issued also in print.
Description based on online resource; title from PDF cover (viewed Feb. 12, 2013).
101601260 [Electronic Resource]

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