Format

Send to:

Choose Destination

Parameters for pesticide QSAR and PBPK/PD models for human risk assessment

Author(s):
Knaak, James B
Timchalk, Charles
Tornero-Velez, Rogelio
American Chemical Society
American Chemical Society Division of Agrochemicals
Title(s):
Parameters for pesticide QSAR and PBPK/PD models for human risk assessment / James B. Knaak, editor, Charles Timchalk, editor, Rogelio Tornero-Velez, editor ; sponsored by the ACS Division of Agrochemicals.
Series:
ACS symposium series ; 1099
Country of Publication:
United States
Publisher:
Washington, DC : American Chemical Society, c2012.
Description:
xii, 349 p. : ill.
Language:
English
ISBN:
9780841226456 (alk. paper)
LCCN:
2012026986
MeSH:
Models, Chemical
Pesticides/toxicity*
Pharmacokinetics
Quantitative Structure-Activity Relationship
Risk Assessment
Publication Type(s):
Congresses
Notes:
Includes bibliographical references and indexes.
Contents:
Parameters for pesticide QSAR and PBPK/PD models to inform human risk assessments -- Chiral chemistry and toxicity assessments for pyrethroid pesticides -- Direct chiral separation of pyrethroid isomers by HPLC with chiral stationary phases -- Biotransformation and enzymes responsible for metabolism of pyrethroids in mammals -- Characterization of potential age-related differences in pyrethroid pharmacokinetics -- 15 factors of percutaneous penetration of pesticides -- Percutaneous absorption of pesticide formulations -- Human metabolic interactions of pesticides : inhibition, induction and activation -- Paraoxonase 1 (PON1) status in risk assessment for organophosphate exposure and pharmacokinetics -- Carboxylesterases : a multifunctional enzyme involved in pesticide and lipid metabolism -- Behavioral changes in adult and young rats as indications of cholinesterase inhibition -- Comparison of esterase sensitivity, metabolic efficiency, and toxicity levels of two organophosphorus insecticides, parathion and chlorpyrifos -- Regional brain dosimetry for the organophosphorus insecticide chlorpyrifos in the preweanling rat -- Pyrethroid actions on sodium channels : isoform and species specificity -- In vitro and in vivo experimental data for development and use of pharmacokinetic models for in vitro to in vivo extrapolation of pyrethroid insecticides -- In silico strategies for modeling stereoselective metabolism of pyrethroids -- Quantitative structure-activity relationships for organophosphate enzyme inhibition -- Computational approaches for developing informative prior distributions for bayesian calibration of PBPK models -- Use of cytochrome P450-specific parameters and human biomarker data to develop a human physiologically based pharmacokinetic/pharmacodynamic model for dermal chlorpyrifos exposure -- Use of in vitro data in PBPK models : an example of in vitro to in vivo extrapolation with carbaryl.
NLM ID:
101588098 [Book]

Supplemental Content

Loading ...
Support Center