Result Filters
Apoptosis, senescence, and cancer
- Author(s):
- Gewirtz, David A
- Holt, Shawn E
- Grant, Steven
- Title(s):
- Apoptosis, senescence, and cancer / edited by David A. Gewirtz, Shawn E. Holt, Steven Grant.
- Series:
- Cancer drug discovery and development
- Edition:
- 2nd ed.
- Country of Publication:
- United States
- Publisher:
- Totowa, N.J. : Humana Press, c2007.
- Description:
- xvii, 599 p. : ill. ; 26 cm.
-
Language:
- English
- ISBN:
- 9781588295279 (alk. paper)
1588295273 (alk. paper)
- LCCN:
- 2007932122
- MeSH:
- Apoptosis*
Cell Transformation, Neoplastic*
Cellular Senescence/drug effects
DNA Damage
Genomic Instability
Neoplasms/drug therapy
- Notes:
- Includes bibliographical references and index.
- Contents:
- The intrinsic pathway of apoptosis -- The extrinsic pathway of apoptosis -- Evaluating the importance of apoptosis and other determinants of cell death and survival -- Mitotic catastrophe -- Autophagy and autophagic cell death -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis -- Structure and function of the telomere -- Overview of senescence -- Contributions of telomerase to tumorigenesis -- The role of telomeres in genomic instability -- Overview of the DNA damage checkpoint: ATM and ATR -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy -- Resistance/signaling pathways -- Ceramide and multidrug resistance -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy -- Antimetabolites -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents -- Tyrosine kinase inhibitors -- Monoclonal antibodies in lymphomas -- Role of apoptosis in anti-angiogenic cancer therapies -- Photodynamic therapy-induced apoptosis -- Modulation of TRAIL signaling for cancer therapy.
- NLM ID:
- 101467266 [Book]