Result Filters
Target proteins database
- Author(s):
- University of Kansas
- NLM Title Abbreviation:
- Target Proteins Database
- Title(s):
- Target proteins database / University of Kansas.
- Other Title(s):
- Protein-small molecule covalent interaction database
- Publication Start Year:
- 2005
- Publication End Year:
- 2020
- Country of Publication:
- United States
- Publisher:
- [Lawrence, Kan.] : University of Kansas
-
Language:
- English
- ISSN:
- 1752-4024 (Electronic)
- LCCN:
- 2012243282
- Electronic Links:
- http://targetprotein.res.ku.edu/
- Summary:
- This database is an attempt to catalog in a convenient, searchable fashion all publicly available information about the identities of mammalian proteins that become covalently adducted by chemically-reactive metabolites of xenobiotic agents including drugs. At present all entries pertain to well-identified proteins that become adducted following defined exposures to known chemical agents in vivo or in cell culture experiments (i.e, "in-life" studies only). Results from studies using enzymatic or chemical model systems are not included but may be in the future. In general, results from studies which expose living cells to intrinsically-reactive chemicals that do not require metabolic activation to react covalently with proteins are excluded. Also excluded from this database is information about the adduction of proteins by endogenous, lipid-derived electrophiles generated under conditions of "oxidative stress" (i.e. the chemical processes of lipid peroxidation or autooxidation).
- Current Indexing Status:
- Not currently indexed for MEDLINE.
- MeSH:
- Proteins/chemistry*
Proteins/drug effects
Proteins/metabolism*
- Publication Type(s):
- Database
- NLM ID:
- 101289988 [Electronic Resource]