My Bibliography

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Kim HC, Zhang Y, King PH, Lu L. MicroRNA-183-5p regulates TAR DNA-binding protein 43 neurotoxicity via SQSTM1/p62 in amyotrophic lateral sclerosis. J Neurochem. 2023 Mar;164(5):643-657. doi: 10.1111/jnc.15744. Epub 2023 Jan 21. PubMed PMID: 36527420.

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Tsitsipatis D, Mazan-Mamczarz K, Si Y, Herman AB, Yang JH, Guha A, Piao Y, Fan J, Martindale JL, Munk R, Yang X, De S, Singh BK, Ho R, Gorospe M, King PH. Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs. Aging (Albany NY). 2022 Dec 30;14(24):9832-9859. doi: 10.18632/aging.204450. Epub 2022 Dec 30. PubMed PMID: 36585921; PubMed Central PMCID: PMC9831722.

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Lopez MA, Si Y, Hu X, Williams V, Qushair F, Carlyle J, Alesce L, Conklin M, Gilbert S, Bamman MM, Alexander MS, King PH. Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133b. Int J Mol Sci. 2022 Jul 7;23(14). doi: 10.3390/ijms23147515. PubMed PMID: 35886863; PubMed Central PMCID: PMC9323105.

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Guha A, Waris S, Nabors LB, Filippova N, Gorospe M, Kwan T, King PH. The versatile role of HuR in Glioblastoma and its potential as a therapeutic target for a multi-pronged attack. Adv Drug Deliv Rev. 2022 Feb;181:114082. doi: 10.1016/j.addr.2021.114082. Epub 2021 Dec 16. Review. PubMed PMID: 34923029; PubMed Central PMCID: PMC8916685.

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Chellappan R, Guha A, Si Y, Kwan T, Nabors LB, Filippova N, Yang X, Myneni AS, Meesala S, Harms AS, King PH. SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation. Glia. 2022 Jan;70(1):155-172. doi: 10.1002/glia.24094. Epub 2021 Sep 17. PubMed PMID: 34533864; PubMed Central PMCID: PMC8595840.

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Kovacs M, Alamón C, Maciel C, Varela V, Ibarburu S, Tarragó L, King PH, Si Y, Kwon Y, Hermine O, Barbeito L, Trias E. The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS. Acta Neuropathol Commun. 2021 Aug 13;9(1):136. doi: 10.1186/s40478-021-01241-3. PubMed PMID: 34389060; PubMed Central PMCID: PMC8361844.

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Si Y, Kazamel M, Benatar M, Wuu J, Kwon Y, Kwan T, Jiang N, Kentrup D, Faul C, Alesce L, King PH. FGF23, a novel muscle biomarker detected in the early stages of ALS. Sci Rep. 2021 Jun 8;11(1):12062. doi: 10.1038/s41598-021-91496-6. PubMed PMID: 34103575; PubMed Central PMCID: PMC8187665.

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Lee I, Kazamel M, McPherson T, McAdam J, Bamman M, Amara A, Smith DL Jr, King PH. Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a prospective study. PLoS One. 2021;16(5):e0251087. doi: 10.1371/journal.pone.0251087. eCollection 2021. PubMed PMID: 33956876; PubMed Central PMCID: PMC8101939.

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Filippova N, Yang X, Ananthan S, Calano J, Pathak V, Bratton L, Vekariya RH, Zhang S, Ofori E, Hayward EN, Namkoong D, Crossman DK, Crowley MR, King PH, Mobley J, Nabors LB. Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors. Cancer Res. 2021 Apr 15;81(8):2220-2233. doi: 10.1158/0008-5472.CAN-20-2858. Epub 2021 Feb 18. PubMed PMID: 33602784; PubMed Central PMCID: PMC8137579.

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Ibarburu S, Kovacs M, Varela V, Rodríguez-Duarte J, Ingold M, Invernizzi P, Porcal W, Arévalo AP, Perelmuter K, Bollati-Fogolín M, Escande C, López GV, King P, Si Y, Kwon Y, Batthyány C, Barbeito L, Trias E. A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition. Neurotherapeutics. 2021 Jan;18(1):309-325. doi: 10.1007/s13311-020-00953-z. Epub 2020 Oct 28. PubMed PMID: 33118131; PubMed Central PMCID: PMC8116482.

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Oh SJ, Lu L, Alsharabati M, Morgan MB, King P. Chronic inflammatory axonal polyneuropathy. J Neurol Neurosurg Psychiatry. 2020 Nov;91(11):1175-1180. doi: 10.1136/jnnp-2020-323787. Epub 2020 Sep 11. PubMed PMID: 32917820.

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Kwan T, Kazamel M, Thoenes K, Si Y, Jiang N, King PH. Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis. Sci Rep. 2020 Oct 7;10(1):16679. doi: 10.1038/s41598-020-73845-z. PubMed PMID: 33028902; PubMed Central PMCID: PMC7541525.

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Rinker JR 2nd, Meador WR, King P. Randomized feasibility trial to assess tolerance and clinical effects of lithium in progressive multiple sclerosis. Heliyon. 2020 Jul;6(7):e04528. doi: 10.1016/j.heliyon.2020.e04528. eCollection 2020 Jul. PubMed PMID: 32760832; PubMed Central PMCID: PMC7393418.

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Trias E, Kovacs M, King PH, Si Y, Kwon Y, Varela V, Ibarburu S, Moura IC, Hermine O, Beckman JS, Barbeito L. Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis. Glia. 2020 Jun;68(6):1165-1181. doi: 10.1002/glia.23768. Epub 2019 Dec 20. PubMed PMID: 31859421; PubMed Central PMCID: PMC7269115.

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Si Y, Kazamel M, Kwon Y, Lee I, Anderson T, Zhou S, Bamman M, Wiggins D, Kwan T, King PH. The vitamin D activator CYP27B1 is upregulated in muscle fibers in denervating disease and can track progression in amyotrophic lateral sclerosis. J Steroid Biochem Mol Biol. 2020 Jun;200:105650. doi: 10.1016/j.jsbmb.2020.105650. Epub 2020 Mar 3. PubMed PMID: 32142934; PubMed Central PMCID: PMC7274892.

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Wang J, Leavenworth JW, Hjelmeland AB, Smith R, Patel N, Borg B, Si Y, King PH. Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth. Glia. 2019 Dec;67(12):2424-2439. doi: 10.1002/glia.23696. Epub 2019 Aug 10. PubMed PMID: 31400163; PubMed Central PMCID: PMC7008520.

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Kovacs M, Trias E, Varela V, Ibarburu S, Beckman JS, Moura IC, Hermine O, King PH, Si Y, Kwon Y, Barbeito L. CD34 Identifies a Subset of Proliferating Microglial Cells Associated with Degenerating Motor Neurons in ALS. Int J Mol Sci. 2019 Aug 9;20(16). doi: 10.3390/ijms20163880. PubMed PMID: 31395804; PubMed Central PMCID: PMC6720880.

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Wang J, Hjelmeland AB, Nabors LB, King PH. Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells. Cancer Biol Ther. 2019;20(7):979-988. doi: 10.1080/15384047.2019.1591673. Epub 2019 Apr 16. PubMed PMID: 30991885; PubMed Central PMCID: PMC6606032.

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Trias E, King PH, Si Y, Kwon Y, Varela V, Ibarburu S, Kovacs M, Moura IC, Beckman JS, Hermine O, Barbeito L. Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS. JCI Insight. 2018 Oct 4;3(19). doi: 10.1172/jci.insight.123249. PubMed PMID: 30282815; PubMed Central PMCID: PMC6237484.

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Si Y, Cui X, Crossman DK, Hao J, Kazamel M, Kwon Y, King PH. Muscle microRNA signatures as biomarkers of disease progression in amyotrophic lateral sclerosis. Neurobiol Dis. 2018 Jun;114:85-94. doi: 10.1016/j.nbd.2018.02.009. Epub 2018 Feb 24. PubMed PMID: 29486297; PubMed Central PMCID: PMC5891369.

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Ardelt AA, Carpenter RS, Iwuchukwu I, Zhang A, Lin W, Kosciuczuk E, Hinkson C, Rebeiz T, Reitz S, King PH. Transgenic expression of HuR increases vasogenic edema and impedes functional recovery in rodent ischemic stroke. Neurosci Lett. 2017 Nov 20;661:126-131. doi: 10.1016/j.neulet.2017.09.062. Epub 2017 Oct 2. PubMed PMID: 28982595; PubMed Central PMCID: PMC5722242.

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Trias E, Ibarburu S, Barreto-Núñez R, Varela V, Moura IC, Dubreuil P, Hermine O, Beckman JS, Barbeito L. Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS. JCI Insight. 2017 Oct 19;2(20). doi: 10.1172/jci.insight.95934. PubMed PMID: 29046475; PubMed Central PMCID: PMC5846907.

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Filippova N, Yang X, Ananthan S, Sorochinsky A, Hackney JR, Gentry Z, Bae S, King P, Nabors LB. Hu antigen R (HuR) multimerization contributes to glioma disease progression. J Biol Chem. 2017 Oct 13;292(41):16999-17010. doi: 10.1074/jbc.M117.797878. Epub 2017 Aug 8. PubMed PMID: 28790173; PubMed Central PMCID: PMC5641879.

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Kwan T, Floyd CL, Patel J, Mohaimany-Aponte A, King PH. Astrocytic expression of the RNA regulator HuR accentuates spinal cord injury in the acute phase. Neurosci Lett. 2017 Jun 9;651:140-145. doi: 10.1016/j.neulet.2017.05.003. Epub 2017 May 6. PubMed PMID: 28487080.

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Matsye P, Zheng L, Si Y, Kim S, Luo W, Crossman DK, Bratcher PE, King PH. HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases. Glia. 2017 Jun;65(6):945-963. doi: 10.1002/glia.23137. Epub 2017 Mar 16. PubMed PMID: 28300326; PubMed Central PMCID: PMC7944581.

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Kwan T, Floyd CL, Kim S, King PH. RNA Binding Protein Human Antigen R Is Translocated in Astrocytes following Spinal Cord Injury and Promotes the Inflammatory Response. J Neurotrauma. 2017 Mar 15;34(6):1249-1259. doi: 10.1089/neu.2016.4757. Epub 2017 Jan 20. PubMed PMID: 27852147; PubMed Central PMCID: PMC5359693.

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Si Y, Kim S, Cui X, Zheng L, Oh SJ, Anderson T, AlSharabati M, Kazamel M, Volpicelli-Daley L, Bamman MM, Yu S, King PH. Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression. PLoS One. 2015;10(9):e0138425. doi: 10.1371/journal.pone.0138425. eCollection 2015. PubMed PMID: 26375954; PubMed Central PMCID: PMC4574401.

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Lu L, Zheng L, Si Y, Luo W, Dujardin G, Kwan T, Potochick NR, Thompson SR, Schneider DA, King PH. Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis. J Biol Chem. 2014 Nov 14;289(46):31792-31804. doi: 10.1074/jbc.M114.573246. Epub 2014 Sep 19. PubMed PMID: 25239623; PubMed Central PMCID: PMC4231657.

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Si Y, Cui X, Kim S, Wians R, Sorge R, Oh SJ, Kwan T, AlSharabati M, Lu L, Claussen G, Anderson T, Yu S, Morgan D, Kazamel M, King PH. Smads as muscle biomarkers in amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2014 Oct;1(10):778-87. doi: 10.1002/acn3.117. Epub 2014 Oct 1. PubMed PMID: 25493269; PubMed Central PMCID: PMC4241805.

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Han X, Li R, Zhang W, Yang X, Wheeler CG, Friedman GK, Province P, Ding Q, You Z, Fathallah-Shaykh HM, Gillespie GY, Zhao X, King PH, Nabors LB. Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro. J Neurooncol. 2014 May;118(1):61-72. doi: 10.1007/s11060-014-1419-0. Epub 2014 Mar 25. PubMed PMID: 24664369; PubMed Central PMCID: PMC4076054.

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King PH, Chen CY. Role of KSRP in control of type I interferon and cytokine expression. J Interferon Cytokine Res. 2014 Apr;34(4):267-74. doi: 10.1089/jir.2013.0143. Review. PubMed PMID: 24697204; PubMed Central PMCID: PMC3976590.

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Kazamel M, Cutter G, Claussen G, Alsharabati M, Oh SJ, Lu L, King PH. Epidemiological features of amyotrophic lateral sclerosis in a large clinic-based African American population. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):334-7. doi: 10.3109/21678421.2013.770030. Epub 2013 Mar 5. PubMed PMID: 23458155; PubMed Central PMCID: PMC3732496.

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Ohira M, Silcox J, Haygood D, Harper-King V, Alsharabati M, Lu L, Morgan MB, Young AM, Claussen GC, King PH, Oh SJ. Electromyography tests in patients with implanted cardiac devices are safe regardless of magnet placement. Muscle Nerve. 2013 Jan;47(1):17-22. doi: 10.1002/mus.23479. Epub 2012 Oct 5. PubMed PMID: 23042608.

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Li X, Lin WJ, Chen CY, Si Y, Zhang X, Lu L, Suswam E, Zheng L, King PH. KSRP: a checkpoint for inflammatory cytokine production in astrocytes. Glia. 2012 Nov;60(11):1773-84. doi: 10.1002/glia.22396. Epub 2012 Jul 28. PubMed PMID: 22847996; PubMed Central PMCID: PMC3629690.

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Filippova N, Yang X, King P, Nabors LB. Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function. J Biol Chem. 2012 Sep 14;287(38):32277-87. doi: 10.1074/jbc.M112.353912. Epub 2012 Jul 24. PubMed PMID: 22829587; PubMed Central PMCID: PMC3442558.

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Wheeler C, Nabors LB, Barnum S, Yang X, Hu X, Schoeb TR, Chen D, Ardelt AA, King PH. Sex hormone-dependent attenuation of EAE in a transgenic mouse with astrocytic expression of the RNA regulator HuR. J Neuroimmunol. 2012 May 15;246(1-2):34-7. doi: 10.1016/j.jneuroim.2012.02.014. Epub 2012 Mar 22. PubMed PMID: 22445740; PubMed Central PMCID: PMC3335935.

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Hill EK, King PH, Hughey LC. Dermatomyositis and concomitant overlap myasthenic syndrome: a rare presentation. J Am Acad Dermatol. 2011 Nov;65(5):e150-2. doi: 10.1016/j.jaad.2011.07.028. PubMed PMID: 22000887.

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Filippova N, Yang X, Wang Y, Gillespie GY, Langford C, King PH, Wheeler C, Nabors LB. The RNA-binding protein HuR promotes glioma growth and treatment resistance. Mol Cancer Res. 2011 May;9(5):648-59. doi: 10.1158/1541-7786.MCR-10-0325. Epub 2011 Apr 15. PubMed PMID: 21498545; PubMed Central PMCID: PMC3096748.

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Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. J Biol Chem. 2009 Dec 4;284(49):33989-98. doi: 10.1074/jbc.M109.067918. Epub 2009 Oct 5. PubMed PMID: 19805546; PubMed Central PMCID: PMC2797169.

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Li X, Lu L, Bush DJ, Zhang X, Zheng L, Suswam EA, King PH. Mutant copper-zinc superoxide dismutase associated with amyotrophic lateral sclerosis binds to adenine/uridine-rich stability elements in the vascular endothelial growth factor 3'-untranslated region. J Neurochem. 2009 Feb;108(4):1032-44. doi: 10.1111/j.1471-4159.2008.05856.x. PubMed PMID: 19196430; PubMed Central PMCID: PMC2646909.

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Meng Z, Jackson NL, Choi H, King PH, Emanuel PD, Blume SW. Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells. J Cell Physiol. 2008 Oct;217(1):172-83. doi: 10.1002/jcp.21486. PubMed PMID: 18452152.

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Suswam E, Li Y, Zhang X, Gillespie GY, Li X, Shacka JJ, Lu L, Zheng L, King PH. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res. 2008 Feb 1;68(3):674-82. doi: 10.1158/0008-5472.CAN-07-2751. PubMed PMID: 18245466.

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Lu L, Zheng L, Viera L, Suswam E, Li Y, Li X, Estévez AG, King PH. Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression. J Neurosci. 2007 Jul 25;27(30):7929-38. doi: 10.1523/JNEUROSCI.1877-07.2007. PubMed PMID: 17652584; PubMed Central PMCID: PMC6672720.

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Rosenfeld SS, Xing J, Jefferson GM, King PH. Docking and rolling, a model of how the mitotic motor Eg5 works. J Biol Chem. 2005 Oct 21;280(42):35684-95. doi: 10.1074/jbc.M506561200. Epub 2005 Aug 22. PubMed PMID: 16115880.

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Suswam EA, Li YY, Mahtani H, King PH. Novel DNA-binding properties of the RNA-binding protein TIAR. Nucleic Acids Res. 2005;33(14):4507-18. doi: 10.1093/nar/gki763. Print 2005. PubMed PMID: 16091628; PubMed Central PMCID: PMC1184220.

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Meng Z, King PH, Nabors LB, Jackson NL, Chen CY, Emanuel PD, Blume SW. The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation. Nucleic Acids Res. 2005;33(9):2962-79. doi: 10.1093/nar/gki603. Print 2005. PubMed PMID: 15914670; PubMed Central PMCID: PMC1140080.

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Suswam EA, Nabors LB, Huang Y, Yang X, King PH. IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. Int J Cancer. 2005 Mar 1;113(6):911-9. doi: 10.1002/ijc.20675. PubMed PMID: 15514971.

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Oh SJ, Gürtekin Y, Dropcho EJ, King P, Claussen GC. Anti-Hu antibody neuropathy: a clinical, electrophysiological, and pathological study. Clin Neurophysiol. 2005 Jan;116(1):28-34. doi: 10.1016/j.clinph.2004.07.012. PubMed PMID: 15589180.

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Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH. Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR. Cancer Res. 2003 Jul 15;63(14):4181-7. PubMed PMID: 12874024.

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Rosenfeld SS, Fordyce PM, Jefferson GM, King PH, Block SM. Stepping and stretching. How kinesin uses internal strain to walk processively. J Biol Chem. 2003 May 16;278(20):18550-6. doi: 10.1074/jbc.M300849200. Epub 2003 Mar 6. PubMed PMID: 12626516; PubMed Central PMCID: PMC1533991.