My Bibliography

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Shin J, Epperson K, Yanjanin NM, Albus J, Borgenheimer L, Bott N, Brennan E, Castellanos D, Cheng M, Clark M, Devany M, Ensslin C, Farivari N, Fernando S, Gabriel L, Gallardo R, Castleman M, Gutierrez O, Herschel A, Hodge S, Horst A, Howard M, James E, Jones L, Kearns M, Kelly M, Kim C, Kiser K, Klazura G, Knoedler C, Kolbus E, Lange L, Lee J, Li E, Lu W, Luttrell A, Ly E, McKeough K, McSorley B, Miller C, Mitchell S, Moon A, Moser K, O'Brien S, Olivieri P, Patzwahl A, Pereira M, Pymento C, Ramelb E, Ramos B, Raya T, Riney S, Roberts G, Robertshaw M, Rudolf F, Rund S, Sansone S, Schwartz L, Shay R, Siu E, Spear T, Tan C, Truong M, Uddin M, Vantrieste J, Veloz O, White E, Porter FD, Haldar K. Defining natural history: assessment of the ability of college students to aid in characterizing clinical progression of Niemann-Pick disease, type C. PLoS One. 2011;6(10):e23666. doi: 10.1371/journal.pone.0023666. Epub 2011 Oct 3. PubMed PMID: 21984891; PubMed Central PMCID: PMC3184943.

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Nagato K, Spear TT, Nishimura MI. Influence of antigen receptor avidity, affinity, and specificity on genetically engineered T cells. In: Want E, Ascierto PA, Stroncek DF, editors. Developments in T Cell Based Cancer New York, NY: Springer; 2015. p.75-98.

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Spear TT, Callender GG, Roszkowski JJ, Moxley KM, Simms PE, Foley KC, Murray DC, Scurti GM, Li M, Thomas JT, Langerman A, Garrett-Mayer E, Zhang Y, Nishimura MI. TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors. Cancer Immunol Immunother. 2016 Mar;65(3):293-304. doi: 10.1007/s00262-016-1800-2. Epub 2016 Feb 3. PubMed PMID: 26842125; PubMed Central PMCID: PMC4887146.

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Blevins SJ, Pierce BG, Singh NK, Riley TP, Wang Y, Spear TT, Nishimura MI, Weng Z, Baker BM. How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1276-85. doi: 10.1073/pnas.1522069113. Epub 2016 Feb 16. PubMed PMID: 26884163; PubMed Central PMCID: PMC4780628.

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Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM. Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes. J Immunol Methods. 2016 May;432:95-101. doi: 10.1016/j.jim.2016.02.016. Epub 2016 Feb 18. PubMed PMID: 26906089; PubMed Central PMCID: PMC4837003.

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Spear TT, Nagato K, Nishimura MI. Strategies to genetically engineer T cells for cancer immunotherapy. Cancer Immunol Immunother. 2016 Jun;65(6):631-49. doi: 10.1007/s00262-016-1842-5. Epub 2016 May 2. Review. PubMed PMID: 27138532; PubMed Central PMCID: PMC5424608.

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Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI. Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. J Leukoc Biol. 2016 Sep;100(3):545-57. doi: 10.1189/jlb.2A1215-561R. Epub 2016 Feb 26. PubMed PMID: 26921345; PubMed Central PMCID: PMC4982612.

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Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM. How an alloreactive T-cell receptor achieves peptide and MHC specificity. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. doi: 10.1073/pnas.1700459114. Epub 2017 Jun 1. PubMed PMID: 28572406; PubMed Central PMCID: PMC5474831.

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Foley KC, Spear TT, Murray DC, Nagato K, Garrett-Mayer E, Nishimura MI. HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer. Mol Ther Oncolytics. 2017 Jun 16;5:105-115. doi: 10.1016/j.omto.2017.05.004. eCollection 2017 Jun 16. PubMed PMID: 28573185; PubMed Central PMCID: PMC5447397.

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Spear TT, Nishimura MI, Simms PE. Comparative exploration of multidimensional flow cytometry software: a model approach evaluating T cell polyfunctional behavior. J Leukoc Biol. 2017 Aug;102(2):551-561. doi: 10.1189/jlb.6A0417-140R. Epub 2017 May 26. PubMed PMID: 28550117; PubMed Central PMCID: PMC6608077.

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Spear TT, Wang Y, Foley KC, Murray DC, Scurti GM, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI. Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells. Cancer Immunol Immunother. 2017 Nov;66(11):1411-1424. doi: 10.1007/s00262-017-2032-9. Epub 2017 Jun 20. PubMed PMID: 28634816; PubMed Central PMCID: PMC5647210.

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Spear TT, Wang Y, Smith TW Jr, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI. Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells. Mol Ther. 2018 Apr 4;26(4):996-1007. doi: 10.1016/j.ymthe.2018.01.015. Epub 2018 Feb 2. PubMed PMID: 29503203; PubMed Central PMCID: PMC6079370.

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Spear TT, Foley KC, Garrett-Mayer E, Nishimura MI. TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependence. J Leukoc Biol. 2018 May;103(5):973-983. doi: 10.1002/JLB.5A0817-314R. Epub 2018 Jan 19. PubMed PMID: 29350789; PubMed Central PMCID: PMC6133711.

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Spear TT, Evavold BD, Baker BM, Nishimura MI. Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy. Cancer Immunol Immunother. 2019 Nov;68(11):1881-1889. doi: 10.1007/s00262-019-02401-0. Epub 2019 Oct 8. Review. PubMed PMID: 31595324; PubMed Central PMCID: PMC11028285.

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Spear TT, Gentile TL. Wilm's Tumor. In: Ferri FF, editor. Ferri's Clinical Advisor 2022 ed. Philadelphia, PA: Elsevier Health Sciences; 2021.

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Spear TT. Red Cell Disorders. In: Tenney Soeiro R, Pete Devon E, editors. Netter's Pediatrics 2 ed. Philadelphia, PA: Elsevier; 2022. Chapter 77; p.462-467.

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Spear TT, Gedminas JM. Bone Neoplasms. In: Tenney Soeiro R, Pete Devon E, editors. Netter's Pediatrics Philadelphia, PA: Elsevier; 2022. Chapter 128; p.761-764.