My Bibliography

select

Kramer G, Blair T, Bambina S, Kaur AP, Alice A, Baird J, Friedman D, Dowdell AK, Tomura M, Grassberger C, Piening BD, Crittenden MR, Gough MJ. Fluorescence tracking demonstrates T cell recirculation is transiently impaired by radiation therapy to the tumor. Sci Rep. 2024 May 24;14(1):11909. doi: 10.1038/s41598-024-62871-w. PubMed PMID: 38789721; PubMed Central PMCID: PMC11126658.

select

Medler TR, Blair TC, Alice AF, Dowdell AK, Piening BD, Crittenden MR, Gough MJ. Myeloid MyD88 restricts CD8(+) T cell response to radiation therapy in pancreatic cancer. Sci Rep. 2023 May 27;13(1):8634. doi: 10.1038/s41598-023-35834-w. PubMed PMID: 37244938; PubMed Central PMCID: PMC10224952.

select

Medler TR, Kramer G, Bambina S, Gunderson AJ, Alice A, Blair T, Zebertavage L, Duhen T, Duhen R, Young K, Crittenden MR, Gough MJ. Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help. Sci Rep. 2023 Apr 18;13(1):6277. doi: 10.1038/s41598-023-33508-1. PubMed PMID: 37072485; PubMed Central PMCID: PMC10113239.

select

Preet Kaur A, Alice A, Crittenden MR, Gough MJ. The role of dendritic cells in radiation-induced immune responses. Int Rev Cell Mol Biol. 2023;378:61-104. doi: 10.1016/bs.ircmb.2023.02.002. Epub 2023 Mar 24. Review. PubMed PMID: 37438021.

select

Kaur AP, Kramer G, Crittenden MR, Gough MJ. Ex vivo analysis of radiation effects on tumor infiltrating immune cells using tumor explants. Methods Cell Biol. 2023;174:55-63. doi: 10.1016/bs.mcb.2022.09.001. Epub 2022 Sep 23. PubMed PMID: 36710051.

select

Bell RB, Gough M, Crittenden M, Young K. Moving beyond the T cell synapse for combination neoadjuvant immunotherapy in head and neck cancer. J Clin Invest. 2022 Sep 15;132(18). doi: 10.1172/JCI162733. PubMed PMID: 36106641; PubMed Central PMCID: PMC9479756.

select

Blair T, Baird J, Bambina S, Kramer G, Gostissa M, Harvey CJ, Gough MJ, Crittenden MR. ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control. Sci Rep. 2022 Sep 2;12(1):14954. doi: 10.1038/s41598-022-19256-8. PubMed PMID: 36056093; PubMed Central PMCID: PMC9440216.

select

Yamazaki T, Gunderson AJ, Gilchrist M, Whiteford M, Kiely MX, Hayman A, O'Brien D, Ahmad R, Manchio JV, Fox N, McCarty K, Phillips M, Brosnan E, Vaccaro G, Li R, Simon M, Bernstein E, McCormick M, Yamasaki L, Wu Y, Drokin A, Carnahan T, To Y, Redmond WL, Lee B, Louie J, Hansen E, Solhjem MC, Cramer J, Urba WJ, Gough MJ, Crittenden MR, Young KH. Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial. Lancet Oncol. 2022 Sep;23(9):1189-1200. doi: 10.1016/S1470-2045(22)00446-6. Epub 2022 Aug 8. PubMed PMID: 35952709.

select

Gough MJ, Crittenden MR. The paradox of radiation and T cells in tumors. Neoplasia. 2022 Sep;31:100808. doi: 10.1016/j.neo.2022.100808. Epub 2022 Jun 9. Review. PubMed PMID: 35691060; PubMed Central PMCID: PMC9194456.

select

Blair TC, Bambina S, Kramer GF, Dowdell AK, Alice AF, Baird JR, Lund AW, Piening BD, Crittenden MR, Gough MJ. Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy. Life Sci Alliance. 2022 Sep;5(9). doi: 10.26508/lsa.202101337. Print 2022 Sep. PubMed PMID: 35487695; PubMed Central PMCID: PMC9058260.

select

Alice AF, Kramer G, Bambina S, Bahjat KS, Gough MJ, Crittenden MR. Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production. Sci Rep. 2021 Aug 11;11(1):16347. doi: 10.1038/s41598-021-95908-5. PubMed PMID: 34381163; PubMed Central PMCID: PMC8358051.

select

Sharon S, Baird JR, Bambina S, Kramer G, Blair TC, Jensen SM, Leidner RS, Bell RB, Casap N, Crittenden MR, Gough MJ. A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection. Oncotarget. 2021 Jun 22;12(13):1201-1213. doi: 10.18632/oncotarget.27982. eCollection 2021 Jun 22. PubMed PMID: 34194619; PubMed Central PMCID: PMC8238246.

select

Sharon S, Duhen T, Bambina S, Baird J, Leidner R, Bell B, Casap N, Crittenden M, Vasudevan S, Jubran M, Kravchenko-Balasha N, Gough M. Explant Modeling of the Immune Environment of Head and Neck Cancer. Front Oncol. 2021;11:611365. doi: 10.3389/fonc.2021.611365. eCollection 2021. PubMed PMID: 34221953; PubMed Central PMCID: PMC8249923.

select

Babiker H, Brana I, Mahadevan D, Owonikoko T, Calvo E, Rischin D, Moreno V, Papadopoulos KP, Crittenden M, Formenti S, Giralt J, Garrido P, Soria A, Hervás-Morón A, Mohan KK, Fury M, Lowy I, Mathias M, Feng M, Li J, Stankevich E. Phase I Trial of Cemiplimab, Radiotherapy, Cyclophosphamide, and Granulocyte Macrophage Colony-Stimulating Factor in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. Oncologist. 2021 Sep;26(9):e1508-e1513. doi: 10.1002/onco.13810. Epub 2021 May 22. PubMed PMID: 33942954; PubMed Central PMCID: PMC8417861.

select

Leidner R, Crittenden M, Young K, Xiao H, Wu Y, Couey MA, Patel AA, Cheng AC, Watters AL, Bifulco C, Morris G, Rushforth L, Nemeth S, Urba WJ, Gough M, Bell RB. Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma. J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2021-002485. PubMed PMID: 33963014; PubMed Central PMCID: PMC8108690.

select

Blair TC, Alice AF, Zebertavage L, Crittenden MR, Gough MJ. The Dynamic Entropy of Tumor Immune Infiltrates: The Impact of Recirculation, Antigen-Specific Interactions, and Retention on T Cells in Tumors. Front Oncol. 2021;11:653625. doi: 10.3389/fonc.2021.653625. eCollection 2021. Review. PubMed PMID: 33968757; PubMed Central PMCID: PMC8101411.

select

Demaria S, Guha C, Schoenfeld J, Morris Z, Monjazeb A, Sikora A, Crittenden M, Shiao S, Khleif S, Gupta S, Formenti SC, Vikram B, Coleman CN, Ahmed MM. Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose?. J Immunother Cancer. 2021 Apr;9(4). doi: 10.1136/jitc-2020-002038. Review. PubMed PMID: 33827904; PubMed Central PMCID: PMC8031689.

select

Medler TR, Blair TC, Crittenden MR, Gough MJ. Defining Immunogenic and Radioimmunogenic Tumors. Front Oncol. 2021;11:667075. doi: 10.3389/fonc.2021.667075. eCollection 2021. Review. PubMed PMID: 33816320; PubMed Central PMCID: PMC8017281.

select

J Gunderson A, Rajamanickam V, Bui C, Bernard B, Pucilowska J, Ballesteros-Merino C, Schmidt M, McCarty K, Philips M, Piening B, Dubay C, Medler T, Newell P, Hansen P, Tran E, Tang E, Bifulco C, Crittenden M, Gough M, Young KH. Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer. Oncoimmunology. 2021 Mar 17;10(1):1900635. doi: 10.1080/2162402X.2021.1900635. PubMed PMID: 33796412; PubMed Central PMCID: PMC7993148.

select

Bernard B, Rajamanickam V, Dubay C, Piening B, Alonso E, Jutric Z, Tang E, Newell P, Hansen P, Medler T, Gunderson A, Young K, Bifulco C, Pucliowska J, Crittenden MR, Gough MJ. Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer. PLoS One. 2020;15(8):e0238380. doi: 10.1371/journal.pone.0238380. eCollection 2020. PubMed PMID: 32866185; PubMed Central PMCID: PMC7458344.

select

Viet CT, Dierks EJ, Cheng AC, Patel AA, Chang SC, Couey MA, Watters AL, Hoang T, Xiao HD, Crittenden MR, Leidner RS, Seung SK, Young KH, Bell RB. Transoral robotic surgery and neck dissection for HPV-positive oropharyngeal carcinoma: Importance of nodal count in survival. Oral Oncol. 2020 Oct;109:104770. doi: 10.1016/j.oraloncology.2020.104770. Epub 2020 Jun 26. PubMed PMID: 32599498.

select

Curti B, Crittenden M, Seung SK, Fountain CB, Payne R, Chang S, Fleser J, Phillips K, Malkasian I, Dobrunick LB, Urba WJ. Randomized phase II study of stereotactic body radiotherapy and interleukin-2 versus interleukin-2 in patients with metastatic melanoma. J Immunother Cancer. 2020 May;8(1). doi: 10.1136/jitc-2020-000773. PubMed PMID: 32467299; PubMed Central PMCID: PMC7259841.

select

Zebertavage LK, Alice A, Crittenden MR, Gough MJ. Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity. Sci Rep. 2020 Apr 30;10(1):7376. doi: 10.1038/s41598-020-64408-3. PubMed PMID: 32355214; PubMed Central PMCID: PMC7193601.

select

Blair TC, Bambina S, Alice AF, Kramer GF, Medler TR, Baird JR, Broz ML, Tormoen GW, Troesch V, Crittenden MR, Gough MJ. Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation Therapy. J Immunol. 2020 Jun 15;204(12):3416-3424. doi: 10.4049/jimmunol.2000194. Epub 2020 Apr 27. PubMed PMID: 32341058; PubMed Central PMCID: PMC7571541.

select

Tormoen GW, Blair TC, Bambina S, Kramer G, Baird J, Rahmani R, Holland JM, McCarty OJT, Baine MJ, Verma V, Nabavizadeh N, Gough MJ, Crittenden M. Targeting MerTK Enhances Adaptive Immune Responses After Radiation Therapy. Int J Radiat Oncol Biol Phys. 2020 Sep 1;108(1):93-103. doi: 10.1016/j.ijrobp.2020.04.013. Epub 2020 Apr 18. PubMed PMID: 32311417; PubMed Central PMCID: PMC7546377.

select

Gunderson AJ, Yamazaki T, McCarty K, Fox N, Phillips M, Alice A, Blair T, Whiteford M, O'Brien D, Ahmad R, Kiely MX, Hayman A, Crocenzi T, Gough MJ, Crittenden MR, Young KH. TGFβ suppresses CD8(+) T cell expression of CXCR3 and tumor trafficking. Nat Commun. 2020 Apr 9;11(1):1749. doi: 10.1038/s41467-020-15404-8. PubMed PMID: 32273499; PubMed Central PMCID: PMC7145847.

select

Gough MJ, Sharon S, Crittenden MR, Young KH. Using Preclinical Data to Design Combination Clinical Trials of Radiation Therapy and Immunotherapy. Semin Radiat Oncol. 2020 Apr;30(2):158-172. doi: 10.1016/j.semradonc.2019.12.002. Review. PubMed PMID: 32381295; PubMed Central PMCID: PMC7213059.

select

Papadopoulos KP, Johnson ML, Lockhart AC, Moore K, Falchook GS, Formenti SC, Naing A, Carvajal RD, Rosen LS, Weiss GJ, Leidner RS, Li J, Paccaly A, Feng M, Stankevich E, Lowy I, Fury MG, Crittenden MR. First-In-Human Study of Cemiplimab Alone or In Combination with Radiotherapy and/or Low-dose Cyclophosphamide in Patients with Advanced Malignancies. Clin Cancer Res. 2020 Mar 1;26(5):1025-1033. doi: 10.1158/1078-0432.CCR-19-2609. Epub 2019 Dec 3. PubMed PMID: 31796520.

select

Couey MA, Bell RB, Patel AA, Romba MC, Crittenden MR, Curti BD, Urba WJ, Leidner RS. Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance. J Immunother Cancer. 2019 Jul 3;7(1):165. doi: 10.1186/s40425-019-0645-6. Review. PubMed PMID: 31269983; PubMed Central PMCID: PMC6609357.

select

Gunderson AJ, Yamazaki T, McCarty K, Phillips M, Alice A, Bambina S, Zebertavage L, Friedman D, Cottam B, Newell P, Gough MJ, Crittenden MR, Van der Veken P, Young KH. Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma. PLoS One. 2019;14(2):e0211117. doi: 10.1371/journal.pone.0211117. eCollection 2019. PubMed PMID: 30726287; PubMed Central PMCID: PMC6364920.

select

Zebertavage L, Bambina S, Shugart J, Alice A, Zens KD, Lauer P, Hanson B, Gough MJ, Crittenden MR, Bahjat KS. A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity. PLoS One. 2019;14(1):e0209153. doi: 10.1371/journal.pone.0209153. eCollection 2019. PubMed PMID: 30601871; PubMed Central PMCID: PMC6314576.

select

Ahmad SS, Crittenden MR, Tran PT, Kluetz PG, Blumenthal GM, Bulbeck H, Baird RD, Williams KJ, Illidge T, Hahn SM, Lawrence TS, Spears PA, Walker AJ, Sharma RA. Clinical Development of Novel Drug-Radiotherapy Combinations. Clin Cancer Res. 2019 Mar 1;25(5):1455-1461. doi: 10.1158/1078-0432.CCR-18-2466. Epub 2018 Nov 29. Review. PubMed PMID: 30498095; PubMed Central PMCID: PMC6397668.

select

Tormoen GW, Crittenden MR, Gough MJ. Role of the immunosuppressive microenvironment in immunotherapy. Adv Radiat Oncol. 2018 Oct-Dec;3(4):520-526. doi: 10.1016/j.adro.2018.08.018. eCollection 2018 Oct-Dec. Review. PubMed PMID: 30370351; PubMed Central PMCID: PMC6200899.

select

Baird JR, Bell RB, Troesch V, Friedman D, Bambina S, Kramer G, Blair TC, Medler T, Wu Y, Sun Z, de Gruijl TD, van de Ven R, Leidner RS, Crittenden MR, Gough MJ. Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma. Cancer Res. 2018 Nov 1;78(21):6308-6319. doi: 10.1158/0008-5472.CAN-18-1652. Epub 2018 Sep 17. PubMed PMID: 30224374.

select

Eggermont AMM, Crittenden M, Wargo J. Combination Immunotherapy Development in Melanoma. Am Soc Clin Oncol Educ Book. 2018 May 23;38:197-207. doi: 10.1200/EDBK_201131. Review. PubMed PMID: 30231333.

select

Crittenden MR, Zebertavage L, Kramer G, Bambina S, Friedman D, Troesch V, Blair T, Baird JR, Alice A, Gough MJ. Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity. Sci Rep. 2018 May 3;8(1):7012. doi: 10.1038/s41598-018-25482-w. PubMed PMID: 29725089; PubMed Central PMCID: PMC5934473.

select

Baird JR, Feng Z, Xiao HD, Friedman D, Cottam B, Fox BA, Kramer G, Leidner RS, Bell RB, Young KH, Crittenden MR, Gough MJ. Correction: STING expression and response to treatment with STING ligands in premalignant and malignant disease. PLoS One. 2018;13(2):e0192988. doi: 10.1371/journal.pone.0192988. eCollection 2018. PubMed PMID: 29447250; PubMed Central PMCID: PMC5813979.

select

Tormoen GW, Crittenden MR, Gough MJ. The TAM family as a therapeutic target in combination with radiation therapy. Emerg Top Life Sci. 2017 Dec;1(5):493-500. doi: 10.1042/etls20170066. Epub 2017 Dec 12. PubMed PMID: 32211517; PubMed Central PMCID: PMC7093058.

select

Alice AF, Kramer G, Bambina S, Baird JR, Bahjat KS, Gough MJ, Crittenden MR. Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity. J Immunol. 2018 Jan 1;200(1):177-185. doi: 10.4049/jimmunol.1700909. Epub 2017 Nov 17. PubMed PMID: 29150567; PubMed Central PMCID: PMC5736417.

select

Baird JR, Feng Z, Xiao HD, Friedman D, Cottam B, Fox BA, Kramer G, Leidner RS, Bell RB, Young KH, Crittenden MR, Gough MJ. STING expression and response to treatment with STING ligands in premalignant and malignant disease. PLoS One. 2017;12(11):e0187532. doi: 10.1371/journal.pone.0187532. eCollection 2017. PubMed PMID: 29135982; PubMed Central PMCID: PMC5685615.

select

Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH. Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial. Lancet Oncol. 2017 Oct;18(10):1373-1385. doi: 10.1016/S1470-2045(17)30517-X. Epub 2017 Aug 23. PubMed PMID: 28844499.

select

Baird JR, Monjazeb AM, Shah O, McGee H, Murphy WJ, Crittenden MR, Gough MJ. Stimulating Innate Immunity to Enhance Radiation Therapy-Induced Tumor Control. Int J Radiat Oncol Biol Phys. 2017 Oct 1;99(2):362-373. doi: 10.1016/j.ijrobp.2017.04.014. Epub 2017 Apr 19. Review. PubMed PMID: 28871985; PubMed Central PMCID: PMC5604475.

select

Sckisel GD, Mirsoian A, Minnar CM, Crittenden M, Curti B, Chen JQ, Blazar BR, Borowsky AD, Monjazeb AM, Murphy WJ. Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy. J Immunother Cancer. 2017;5:33. doi: 10.1186/s40425-017-0235-4. eCollection 2017. PubMed PMID: 28428882; PubMed Central PMCID: PMC5394626.

select

Bell RB, Gough MJ, Seung SK, Jutric Z, Weinberg AD, Fox BA, Crittenden MR, Leidner RS, Curti B. Erratum to 'Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy' [Oral Oncol. 61 (2016) 166-176]. Oral Oncol. 2017 Mar;66:e3. doi: 10.1016/j.oraloncology.2017.02.001. Epub 2017 Feb 12. PubMed PMID: 28202215.

select

Crittenden MR, Baird J, Friedman D, Savage T, Uhde L, Alice A, Cottam B, Young K, Newell P, Nguyen C, Bambina S, Kramer G, Akporiaye E, Malecka A, Jackson A, Gough MJ. Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy. Oncotarget. 2016 Nov 29;7(48):78653-78666. doi: 10.18632/oncotarget.11823. PubMed PMID: 27602953; PubMed Central PMCID: PMC5346667.

select

Friedman D, Baird JR, Young KH, Cottam B, Crittenden MR, Friedman S, Gough MJ, Newell P. Programmed cell death-1 blockade enhances response to stereotactic radiation in an orthotopic murine model of hepatocellular carcinoma. Hepatol Res. 2017 Jun;47(7):702-714. doi: 10.1111/hepr.12789. Epub 2016 Sep 22. PubMed PMID: 27501850.

select

Bryan RB, Gough MJ, Seung SK, Jutric Z, Weinberg AD, Fox BA, Crittenden MR, Leidner RS, Curti B. Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy. Oral Oncol. 2016 Oct;61:166-76. doi: 10.1016/j.oraloncology.2016.08.020. Epub 2016 Sep 7. Review. PubMed PMID: 27614589.

select

Crocenzi T, Cottam B, Newell P, Wolf RF, Hansen PD, Hammill C, Solhjem MC, To YY, Greathouse A, Tormoen G, Jutric Z, Young K, Bahjat KS, Gough MJ, Crittenden MR. A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma. J Immunother Cancer. 2016;4:45. doi: 10.1186/s40425-016-0149-6. eCollection 2016. PubMed PMID: 27532020; PubMed Central PMCID: PMC4986363.

select

Young KH, Baird JR, Savage T, Cottam B, Friedman D, Bambina S, Messenheimer DJ, Fox B, Newell P, Bahjat KS, Gough MJ, Crittenden MR. Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy. PLoS One. 2016;11(6):e0157164. doi: 10.1371/journal.pone.0157164. eCollection 2016. PubMed PMID: 27281029; PubMed Central PMCID: PMC4900555.

select

Bell RB, Leidner R, Feng Z, Crittenden MR, Gough MJ, Fox BA. Developing an Immunotherapy Strategy for the Effective Treatment of Oral, Head and Neck Squamous Cell Carcinoma. J Oral Maxillofac Surg. 2015 Dec;73(12 Suppl):S107-15. doi: 10.1016/j.joms.2015.05.026. Review. PubMed PMID: 26608138.