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Catechol O-Methyltransferase Inhibitors
Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.
Year introduced: 2015
Catechol 2,3-Dioxygenase
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
Year introduced: 2006(1981)
Catechol 1,2-Dioxygenase
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. This enzyme was formerly characterized as EC 1.13.1.1 and EC 1.99.2.2.
Year introduced: 2006(1980)
Catechol Oxidase
An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yield benzoquinone and water. It is a complex of copper-containing proteins that acts also on a variety of substituted catechols. EC 1.10.3.1.
Year introduced: 1992
Catechol O-Methyltransferase
Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a catecholamine.
Year introduced: 1998(1972)
Estrogens, Catechol
2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.
Year introduced: 1994
Catechols
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Year introduced: 1975
Catechin
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
Year introduced: 1987(1977)
catechol [Supplementary Concept]
RN given refers to unlabeled parent cpd
Date introduced: May 5, 1982
p-tert-butyl catechol [Supplementary Concept]
Date introduced: January 1, 1978
Guaiacol
An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747)
tamoxifen catechol [Supplementary Concept]
structure in first source
Date introduced: July 15, 1999
catechol-(2-(diethylamino)carbonyl-4-bromomethyl)phenylboronate [Supplementary Concept]
Date introduced: August 4, 1997
3-trimethylaminomethylcatechol [Supplementary Concept]
structure given in first source
Date introduced: October 28, 1982
Catechol O-Methyltransferase Inhibitors [Pharmacological Action]
COMT protein, human [Supplementary Concept]
RefSeq NM_000754
Date introduced: April 24, 2014
4-((E)-2'-(S)-glutathionyl ethenyl)catechol [Supplementary Concept]
Date introduced: January 24, 2014
4,5-dimercaptocatechol [Supplementary Concept]
Date introduced: December 2, 2009
3-(8',11'-pentadecadienyl)catechol [Supplementary Concept]
has antineoplastic activity; structure in first source
Date introduced: August 1, 2009
4-((quinolin-4-yl)vinyl)catechol [Supplementary Concept]
Date introduced: July 30, 2007