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beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Year introduced: 2006(1992)
Axin Signaling Complex
A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.
Year introduced: 2012
Wnt Signaling Pathway
A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.
CTNNBL1 protein, mouse [Supplementary Concept]
CTNNBL1 - catenin (cadherin-associated protein), beta-like 1; RefSeq NM_025680
Date introduced: September 7, 2010
Dact1 protein, rat [Supplementary Concept]
RefSeq XM_576044
Date introduced: August 30, 2005
Ctnnbip1 protein, mouse [Supplementary Concept]
RefSeq NM_023465
Date introduced: July 29, 2005
dact1 protein, zebrafish [Supplementary Concept]
RefSeq NM_214731
Date introduced: February 19, 2005
Atxn10 protein, rat [Supplementary Concept]
RefSeq NM_133313
Date introduced: February 13, 2005
ARM protein, Drosophila [Supplementary Concept]
RefSeq NM_057318
CTNNB1 protein, human [Supplementary Concept]
RefSeq NM_001098210
ctnnb1 protein, zebrafish [Supplementary Concept]
RefSeq NM_131059
Ctnnb1 protein, rat [Supplementary Concept]
RefSeq NM_053357
CTNNB1 protein, mouse [Supplementary Concept]
RefSeq NM_007614
CTNNB1 protein, Xenopus [Supplementary Concept]
dact2 protein, zebrafish [Supplementary Concept]
RefSeq NM_001077794
Date introduced: October 23, 2004
DACT1 protein, human [Supplementary Concept]
RefSeq NM_016651
Date introduced: November 2, 2004
CTNNBL1 protein, human [Supplementary Concept]
CTNNBL1 - catenin (cadherin-associated protein), beta-like 1; may be involved in apoptosis; RefSeq NM_030877
Date introduced: December 7, 2003
DACT2 protein, human [Supplementary Concept]
a putative Dishevelled-binding protein associated with cancer; RefSeq NM_214462
Date introduced: November 10, 2003
Chd8 protein, rat [Supplementary Concept]
RefSeq NM_022933
Date introduced: November 17, 2000