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Vitamin D-Binding Protein
An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.
Year introduced: 1985
vitamin D-binding protein-macrophage activating factor [Supplementary Concept]
formed when deglycosylated at O-linked site near C-terminus; incubation of human group-specific component with mixture of beta-galactosidase and sialidase generates macrophage activating factor, GcMAF
Date introduced: November 25, 1996
GC protein, human [Supplementary Concept]
RefSeq NM_000583
Date introduced: October 26, 2018
vitamin D binding protein 2, primate [Supplementary Concept]
amino acid sequence in first source
Date introduced: January 3, 2001
vitamin D binding protein 1, primate [Supplementary Concept]