Vascular Endothelial Growth Factor A - MeSH

Select item 680424611.

Vascular Endothelial Growth Factor A

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

Year introduced: 2004

Select item 674674982.

vascular endothelial growth factor A, rat [Supplementary Concept]

GenBank U22372

Date introduced: November 5, 2002

Select item 674674843.

VEGFA protein, human [Supplementary Concept]

RefSeq NM_001025366

Date introduced: November 5, 2002

Select item 674674804.

vascular endothelial growth factor A, mouse [Supplementary Concept]

numbered proteins refer to isoforms due to alternative mRNA splicing; RefSeq NM_009505