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A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).


Pediatric Obesity

BODY MASS INDEX in children (ages 2-12) and in adolescents (ages 13-18) that is grossly above the recommended cut-off for a specific age and sex. For infants less than 2 years of age, obesity is determined based on standard weight-for-length percentile measures.

Year introduced: 2014


Obesity, Abdominal

A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as DIABETES; HYPERTENSION; and METABOLIC SYNDROME.

Year introduced: 2010


Anti-Obesity Agents

Agents that increase energy expenditure and weight loss by neural and metabolic regulation.

Year introduced: 1997


Obesity Hypoventilation Syndrome

HYPOVENTILATION syndrome in very obese persons with excessive ADIPOSE TISSUE around the ABDOMEN and DIAPHRAGM. It is characterized by diminished to absent ventilatory chemoresponsiveness; chronic HYPOXIA; HYPERCAPNIA; POLYCYTHEMIA; and long periods of sleep during day and night (HYPERSOMNOLENCE). It is a condition often related to OBSTRUCTIVE SLEEP APNEA but can occur separately.

Year introduced: 2006 (1970)


Obesity, Morbid

The condition of weighing two, three, or more times the ideal weight, so called because it is associated with many serious and life-threatening disorders. In the BODY MASS INDEX, morbid obesity is defined as having a BMI greater than 40.0 kg/m2.

Year introduced: 1987


Obesity Paradox

An observation that high BODY MASS INDEX is sometimes associated with lower CARDIOVASCULAR DISEASE mortality in certain population, e.g., ELDERLY.

Year introduced: 2023


Obesity, Maternal

BODY MASS INDEX in PREGNANT WOMEN that is excessively above the recommended cut-off.

Year introduced: 2020


Obesity Management

An integrated professional approach to screening, evaluation, control, and reduction of abnormal WEIGHT GAIN.

Year introduced: 2018


Obesity, Metabolically Benign

A sub-PHENOTYPE of obese individuals who have a risk for CARDIOVASCULAR DISEASES between that of healthy individuals with normal weight and unhealthy individuals with obesity.

Year introduced: 2016


Ayazi syndrome [Supplementary Concept]

Date introduced: August 25, 2010


Cohen syndrome [Supplementary Concept]

A rare autosomal recessive disorder that occurs primarily in the Finnish population where it is characterized by non-progressive mild to severe psychomotor retardation, microcephaly, characteristic facial features (high-arched or wave-shaped eyelids, a short lip, thick hair, and low hairline), childhood hypotonia and joint laxity, progressive retinochoroidal dystrophy, myopia, intermittent isolated NEUTROPENIA, and a cheerful disposition. Obesity, retinochoroidal dystrophy, and neutropenia are far less common in non-Finnish patients. Mutations in the VPS13B gene have been identified. OMIM: 216550

Date introduced: August 25, 2010


MORM syndrome [Supplementary Concept]

Date introduced: August 25, 2010


Abdominal obesity metabolic syndrome [Supplementary Concept]

AOMS1 not included

Date introduced: June 25, 2010


FTO protein, mouse [Supplementary Concept]

bioinformatics analysis shows FTO shares sequence motifs with Fe(II)- & 2-oxoglutarate-dependent oxygenases; recombinant Fto catalyzes the Fe(II)- & 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA; Fto mRNA is most abundant in brain; RefSeq NM_011936

Date introduced: December 12, 2007


Weight Prejudice

Negative attitudes towards and beliefs about others because of their weight. These negative attitudes are manifested by stereotypes and/or prejudice towards people with weight over or under a cultural norm.

Year introduced: 2020


Alpha-Ketoglutarate-Dependent Dioxygenase FTO

A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

Year introduced: 2017

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