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rev Gene Products, Human Immunodeficiency Virus
Proteins encoded by the REV GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Year introduced: 2008
nef Gene Products, Human Immunodeficiency Virus
Proteins encoded by the NEF GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Fusion Regulatory Protein-1
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (FUSION REGULATORY PROTEIN 1, HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (FUSION REGULATORY PROTEIN 1, LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Year introduced: 2018 (1988)
tat Gene Products, Human Immunodeficiency Virus
Proteins encoded by the TAT GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
Tumor Protein p73
A homolog of p53 TUMOR SUPPRESSOR PROTEIN that encodes full-length trans-activating and N-terminally-truncated (DeltaN) isoforms. Detection of splice variants and isoforms in the nervous system (human TELENCEPHALON, CHOROID PLEXUS; CEREBROSPINAL FLUID), embryonic tissue, human BREAST CANCER; OVARIAN CANCER, suggest roles in cellular differentiation.
Year introduced: 2017 (1997)
vpr Gene Products, Human Immunodeficiency Virus
Proteins encoded by the VPR GENES of the HUMAN IMMUNODEFICIENCY VIRUS.
HIV Core Protein p24
A major core protein of the human immunodeficiency virus encoded by the HIV gag gene. HIV-seropositive individuals mount a significant immune response to p24 and thus detection of antibodies to p24 is one basis for determining HIV infection by ELISA and Western blot assays. The protein is also being investigated as a potential HIV immunogen in vaccines.
Year introduced: 1992
oxysterol binding protein [Supplementary Concept]
binds oxygenated sterols which repress 3-hydroxy-3-methylglutaryl(HMG)-CoA reductase
Date introduced: March 21, 1988
coronin proteins [Supplementary Concept]
actin-binding proteins of 49 KDa with sequence similarities to G protein Beta subunits
Date introduced: January 30, 1992
protein kinase N [Supplementary Concept]
homologous to protein kinase C; nerve growth factor-activated serine protein kinase that is active in the presence of Mn++
Date introduced: December 4, 1989
signal sequence receptor [Supplementary Concept]
part of a translocation complex in the endoplasmic reticulum; RefSeq NM_003145 (SSR2, human); NM_003144 (SSR1, human); NM_006280 (SSR4, human); NM_009279 (Ssr4, mouse); NM_017199 (Ssr4, rat)
Date introduced: February 26, 1991
keratin-associated protein 5 family, human [Supplementary Concept]
KAP - Keratin-Associated Protein; KAP5 gene expression in hair follicles is regulated by Runx1
Date introduced: June 19, 2006
cif nucleoside transporter [Supplementary Concept]
sodium-dependent purine nucleoside transporter; RefSeq NM_053863 (Slc28a1, rat); NM_031664 (Slc28a2, rat); NM_080908 (Slc28a3, rat); NM_004213 (SLC28A1, human); NM_004212 (SLC28A2, human); NM_022127 (SLC28A3, human); NM_172980 (Slc28a2, mouse); NM_022317 (Slc28a3, mouse)
Date introduced: September 6, 1990
interferon-lambda, human [Supplementary Concept]
Date introduced: November 1, 2017
neuronal pentraxin [Supplementary Concept]
Nptx1 is a secreted protein with homology to acute phase proteins of the immune system and is involved in the general uptake of synaptic macromolecules; RefSeq NM_153735 (rat); NM_002522 (NPTX1, human); NM_002523 (NPTX2, human); NM_008730 (Nptx1, mouse); NM_058178 (NPTXR, human); NM_028763 (Nptxr, mouse); NM_030841 (Nptxr, rat); NM_008987 (Ptx3, mouse)
Date introduced: April 28, 1995
peptidoglycan recognition protein [Supplementary Concept]
RefSeq NM_052890 (PGLYRP2, human); NM_052891 (PGLYRP3, human); NM_020393 (PGLYRP4, human)
Date introduced: May 19, 1999
TP63 protein, human [Supplementary Concept]
RefSeq NM_003722
Date introduced: October 30, 1998
sodium-hydrogen exchanger regulatory factor [Supplementary Concept]
a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na+-H+ exchanger; 358 amino acids, MW 55 kDa; partial amino acid sequence given in first source
Date introduced: June 2, 1995
MAPKAP1 protein, human [Supplementary Concept]
RefSeq NM_001006620
Date introduced: November 24, 2004
taste receptors, type 2 [Supplementary Concept]
G protein-coupled bitter taste receptors
Date introduced: April 25, 2000