Isocitrate Dehydrogenase - MeSH

Select item 680075211.

An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.

Year introduced: 1965(1963)

Select item 20292402.

IDH3A protein, human [Supplementary Concept]

RefSeq NM_005530

Date introduced: April 1, 2019

Select item 675480233.

AceK protein, E coli [Supplementary Concept]

RefSeq YP_ 002410278

Date introduced: March 24, 2010

Select item 675387844.

IDH2 protein, human [Supplementary Concept]

RefSeq NM_002168

Date introduced: February 27, 2009

Select item 671041445.

NELL1 protein, human [Supplementary Concept]

RefSeq NM_006157

Date introduced: February 28, 1997

Select item 670393556.

isocitrate dehydrogenase (NADP+) [Supplementary Concept]

IDP1 is a mitochondrial isozyme; IDP2 is the cytosolic isozyme; IDP3 is peroxisomal

Date introduced: November 4, 1983

Select item 20292417.

IDH3b protein, human [Supplementary Concept]

RefSeq NM_001258384

Date introduced: April 2, 2019

Select item 20076718.

isocitrate dehydrogenase 2, mouse [Supplementary Concept]

RefSeq NM_173011

Date introduced: July 23, 2015

Select item 675435889.

IDH1 protein, human [Supplementary Concept]

RefSeq NM_005896

Date introduced: September 17, 2009

Select item 6747562910.

isocitrate dehydrogenase II, Mycobacterium bovis [Supplementary Concept]

82 kDa protein of potential use in serodiagnosis of tuberculosis; has been sequenced

Date introduced: July 17, 2003

Select item 6704230111.

isocitrate dehydrogenase kinase [Supplementary Concept]

catalyzes the phosphorylation of homogeneous active isocitrate dehydrogenase; can use only ATP as phosphate donor; part of the same protein as isocitrate dehydrogenase phosphatase

Date introduced: August 21, 1984

Select item 6704230012.

isocitrate dehydrogenase phosphatase [Supplementary Concept]

catalyzes the release of phosphorus from phosphorylated isocitrate dehydrogenase; requires ADP or ATP for activity; part of the same protein as isocitrate dehydrogenase kinase

Date introduced: August 21, 1984

Select item 202994313.

Idh2 protein, rat [Supplementary Concept]

RefSeq NM_001014161

Date introduced: September 16, 2019

Select item 202780914.

Idh1 protein, mouse [Supplementary Concept]

RefSeq NM_010497

Date introduced: November 15, 2018

Select item 202690215.

Idh3b protein, Drosophila [Supplementary Concept]

RefSeq: NM_001170211