Fusion Proteins, bcr-abl
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Year introduced: 1991
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Tree Number(s): D08.811.913.696.620.682.725.500.500, D12.776.476.568.500.500, D12.776.602.500.500.100, D12.776.624.664.500.100, D12.776.624.664.700.171.500
MeSH Unique ID: D016044
Registry Number: EC 2.7.10.2
Entry Terms:
- Fusion Proteins, bcr abl
- Bcr-Abl Tyrosine Kinase
- Bcr Abl Tyrosine Kinase
- Kinase, Bcr-Abl Tyrosine
- Tyrosine Kinase, Bcr-Abl
- bcr-abl Fusion Proteins
- bcr abl Fusion Proteins
- bcr-abl Fusion Protein
- Fusion Protein, bcr-abl
- Protein, bcr-abl Fusion
- bcr abl Fusion Protein
- Oncogene Protein p190(bcr-abl)
- p190(bcr-abl) Fusion Proteins
- Oncogene Protein p230(bcr-abl)
- p230(bcr-abl) Fusion Proteins
- Oncogene Protein p185(bcr-abl)
- p185(bcr-abl) Fusion Proteins
- Oncogene Protein p210(bcr-abl)
- p210(bcr-abl) Fusion Proteins
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