MeSH

A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LYMPHOID CELLS. In the CENTRAL NERVOUS SYSTEM focal adhesion kinase 2 modulates ION CHANNEL function and MITOGEN-ACTIVATED PROTEIN KINASES activity.

Year introduced: 2006(1995)

RefSeq NM_017318

Date introduced: July 29, 2005

RefSeq NM_172498

Date introduced: July 29, 2005

a rho GTPase-activating signaling protein essential for PYK2 regulation of cytoskeletal organization via Rho family GTPases; full length of Graf2 contains a putative PH domain, a RhoGAP domain, and an SH3 domain as well as Graf; PKNbeta interacts with the SH3 domains of Graf & Graf2; RefSeq NM_024605

Date introduced: August 6, 2004

RefSeq NM_004103

Date introduced: February 5, 1997