DEAD Box Protein 58

A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

Year introduced: 2017

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Tree Number(s): D08.811.913.696.445.735.720.249.750

MeSH Unique ID: D000071457

Registry Number: EC 3.6.4.13

Entry Terms:

• DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
• Probable ATP-Dependent RNA Helicase DDX58
• Probable ATP Dependent RNA Helicase DDX58
• RIG-I-like Receptor 1
• RIG I like Receptor 1

Previous Indexing:

• DEAD-box RNA Helicases (2006-2016)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Nucleotidyltransferases
RNA Nucleotidyltransferases
RNA Helicases
DEAD-box RNA Helicases
DEAD Box Protein 58