MeSH

Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.

Year introduced: 1991

Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.

Year introduced: 2006(1991)

RefSeq NM_176795

Date introduced: July 29, 2005

reagent used to catalyze intramolecular C-H insertion reactions; structure in first source

Date introduced: October 27, 2004

amyloid-reactive antibody; was produced in CHOdhfr-stable mammalian cell lines that had been transfected with a supervector DNA encoding the mouse 11-1F4 heavy and light chain variable regions (V(H), V(L)) and human heavy and light chain constant regions (C(H), C(L)), chimera of human and mouse

Date introduced: May 28, 2004

used tor 1,5 C-H bond insertion of alkylidenecarbenes

Date introduced: April 12, 2002

a soluble protein with alpha/beta-type secondary structure; expressed early in floral development, controls carpel cell number, and has a sequence suggesting structural similarity to the human oncogene c-H-ras p21; amino acid sequence in first source

Date introduced: July 17, 2000

RefSeq NM_019396

Date introduced: April 26, 2000

Date introduced: April 27, 1984