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Interleukin-8
A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.
Year introduced: 1991
Receptors, Interleukin-8
Cell surface receptors that are specific for INTERLEUKIN-8. Two specific receptor subtypes (type A and B) have been found and bind IL-8 with high affinity.
Year introduced: 2007
Receptors, Interleukin-8B
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.
Year introduced: 2001
Receptors, Interleukin-8A
High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and BASOPHILS.
CTSL protein, human [Supplementary Concept]
RefSeq NM_001912
Date introduced: August 13, 2009
SpyCEP protein, Streptococcus pyogenes [Supplementary Concept]
cleaves both GCP-2 and GROalpha
Date introduced: March 17, 2008
ABX-Interleukin 8 [Supplementary Concept]
a fully human monoclonal IgG2 antibody directed against interleukin-8 for treatment of patients with Pulmonary Disease, Chronic Obstructive
Date introduced: November 1, 2004
Physiomer [Supplementary Concept]
reduces the chemokine interleukin-8 production by activated human respiratory epithelial cells; an isotonic sterile, undiluted sea water-derived solution containing a low final concentration of Na+ (2,400 mg.L(-1)), commercialized for the cleaning of human nasal mucosa
Date introduced: March 7, 2002
SB 225002 [Supplementary Concept]
a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration; structure in first source
Date introduced: May 21, 1998
PicB protein, Helicobacter pylori [Supplementary Concept]
26% identical to PtlC protein; required for induction of interleukin-8 in gastric epithelial cells; isolated from Helicobacter pylori; amino acid sequence in first source
Date introduced: February 19, 1997
endothelial neutrophil activating peptide [Supplementary Concept]
a monocyte-macrophage derived cytokine of the interleukin-8 family; 73% amino acid sequence identity with ENA-78; amino acid sequence given in first source
Date introduced: January 5, 1995
interleukin-8 (3-25) [Supplementary Concept]
inhibits the neutrophil chemotactic activity of preheated recombinant IL-9
Date introduced: July 28, 1994
interleukin 8 (77), Ala- [Supplementary Concept]
interleukin 8 with a pentapeptide extension at the NH2 terminus; produced by endothelial cells; a potent inhibitor of neutrophil adhesion to cytokine-activated endothelial monolayers & protects these monolayers from neutrophil-mediated damage
Date introduced: September 26, 1991
ETH 615 [Supplementary Concept]
leukotriene B4 and interleukin-8 antagonist; structure in first source
Date introduced: August 20, 1991
HuMax-IL8 [Supplementary Concept]
fully human monoclonal antibody that inhibits interleukin-8 (IL-8)
Date introduced: August 12, 2020
Cxcl8-l1, zebrafish [Supplementary Concept]
RefSeq XM_001342570
Date introduced: August 24, 2015
Cajanus lactone [Supplementary Concept]
inhibits production of both tumor necrosis factor alpha and interleukin-8; isolated from Cajanus cajan; structure in first source
Date introduced: May 20, 2015
terminolic acid [Supplementary Concept]
from Melastoma dodecandrum with inhibitory activity on interleukin-8 production in HT-29 cells; structure in first source
Date introduced: December 2, 2014
CXCL8 protein, human [Supplementary Concept]
RefSeq NM_000584
Date introduced: March 13, 2006
technetium Tc 99m interleukin 8 [Supplementary Concept]
Date introduced: August 29, 2001