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Multiple Endocrine Neoplasia Type 2a

A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.

Year introduced: 1995

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Tree Number(s): C04.588.322.400.505, C04.651.600.505, C04.700.630.505, C16.320.700.630.505, C19.344.400.505

MeSH Unique ID: D018813

Entry Terms:

  • MEA II
  • MEA IIa
  • MEN 2
  • MEN 2a
  • MEN II
  • MEN IIa
  • MEN-2A Syndrome
  • MEN 2A Syndrome
  • MEN-2A Syndromes
  • MEN2a
  • Multiple Endocrine Neoplasia Type 2
  • Multiple Endocrine Neoplasms Type 2a
  • Neoplasia, Multiple Endocrine Type 2a
  • Neoplasms, Multiple Endocrine Type 2a
  • Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
  • Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
  • Sipple Syndrome
  • Multiple Endocrine Neoplasia, Type IIa
  • MEA 2a

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