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Multiple Endocrine Neoplasia Type 1

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

Year introduced: 1995

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Subheadings:

Tree Number(s): C04.588.322.400.500, C04.651.600.500, C04.700.630.500, C16.320.700.630.500, C19.344.400.500

MeSH Unique ID: D018761

Entry Terms:

  • MEN I
  • Wermer Syndrome
  • Neoplasia, Multiple Endocrine Type 1
  • MEN1
  • Neoplasms, Multiple Endocrine Type 1
  • MEN 1
  • MEA 1
  • Multiple Endocrine Neoplasia Type I
  • Neoplasms, Multiple Endocrine Type I
  • MEA I
  • Multiple Endocrine Neoplasms Type 1

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