Calreticulin
A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Year introduced: 2003
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Subheadings:
Tree Number(s): D12.644.360.372.374, D12.776.157.125.412.374, D12.776.476.387.374, D12.776.503.303
MeSH Unique ID: D037282
Entry Terms:
- CAB-63
- CBP3 (Liver)
- ERp60
- 55-kDa High-Affinity Calcium Binding Protein
- 55 kDa High Affinity Calcium Binding Protein
- cC1qR Protein
- Calcium-Binding Protein-3
- Calcium Binding Protein 3
- Calregulin
- HACBP
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