src Homology Domains

Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.

Year introduced: 1996

Date introduced: January 6, 1995

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): G02.111.570.820.709.275.750.500.750

MeSH Unique ID: D018909

Entry Terms:

• Homology Domain, src
• Homology Domains, src
• src Homology Domain
• SH Domains
• SH Domain
• SH1 Domain
• SH1 Domains
• SH2 Domain
• SH2 Domains
• src Homology Region 2 Domain
• SH3 Domain
• SH3 Domains

Previous Indexing:

• Amino Acid Sequence (1989-1995)
• Sequence Homology, Amino Acid (1993-1995)

All MeSH Categories
Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Molecular Structure
Molecular Conformation
Protein Conformation
Protein Structural Elements
Protein Domains
Protein Interaction Domains and Motifs
src Homology Domains