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beta 2-Microglobulin

An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.

Year introduced: 1991 (1975)

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Tree Number(s): D12.776.124.790.223.100, D12.776.377.715.182.100, D12.776.395.550.489.100, D12.776.543.550.439.100, D23.050.301.500.100.175, D23.050.705.552.100.175

MeSH Unique ID: D001613

Entry Terms:

  • beta 2 Microglobulin
  • Thymotaxin

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