Vascular Endothelial Growth Factor A
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Year introduced: 2004
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Subheadings:
Tree Number(s): D12.644.276.100.800.200, D12.776.467.100.800.200, D23.529.100.800.200
MeSH Unique ID: D042461
Entry Terms:
- Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor-A
- Vascular Permeability Factor
- Permeability Factor, Vascular
- Vasculotropin
- VEGF
- VEGF-A
- Glioma-Derived Vascular Endothelial Cell Growth Factor
- Glioma Derived Vascular Endothelial Cell Growth Factor
- GD-VEGF
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