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Ubiquitin-Protein Ligase Complexes

Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).

Year introduced: 2004

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Tree Number(s): D08.811.464.938

MeSH Unique ID: D043743

Registry Number: EC 2.3.2.23

Entry Terms:

  • Complexes, Ubiquitin-Protein Ligase
  • Ligase Complexes, Ubiquitin-Protein
  • Ubiquitin Protein Ligase Complexes

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