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Tumor Necrosis Factor-alpha

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Year introduced: 2005(1988)

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Tree Number(s): D12.644.276.374.500.800, D12.644.276.374.750.626, D12.776.124.900, D12.776.395.930, D12.776.467.374.500.800, D12.776.467.374.750.626, D23.529.374.500.800, D23.529.374.750.626

MeSH Unique ID: D014409

Entry Terms:

  • Tumor Necrosis Factor alpha
  • Cachectin
  • Cachectin-Tumor Necrosis Factor
  • Cachectin Tumor Necrosis Factor
  • Tumor Necrosis Factor Ligand Superfamily Member 2
  • Tumor Necrosis Factor
  • TNF Superfamily, Member 2
  • TNFalpha
  • TNF-alpha

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