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Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

Year introduced: 2002(1986)

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Tree Number(s): D08.811.913.050.200.800

MeSH Unique ID: D011503

Registry Number: EC

Entry Terms:

  • Protein-Glutamine gamma-Glutamyltransferases
  • Protein Glutamine gamma Glutamyltransferases
  • gamma-Glutamyltransferases, Protein-Glutamine
  • Glutaminyl-Peptide Gamma-Glutamyltransferases
  • Gamma-Glutamyltransferases, Glutaminyl-Peptide
  • Glutaminyl Peptide Gamma Glutamyltransferases

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