Transforming Growth Factor beta1
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Year introduced: 2007(1992)
Date introduced: July 5, 2006
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Tree Number(s): D12.644.276.374.687.100, D12.644.276.954.775.100, D12.776.467.374.687.100, D12.776.467.942.775.100, D23.529.374.687.100, D23.529.942.775.100
MeSH Unique ID: D053773
Entry Terms:
- Transforming Growth Factor-beta1
- TGF-beta-1
- TGF beta 1
- TGF-beta1
- Transforming Growth Factor beta I
- Transforming Growth Factor beta 1 Latency Associated Peptide
- TGF-beta1 Latency-Associated Protein
- Latency-Associated Protein, TGF-beta1
- TGF beta1 Latency Associated Protein
- TGF-beta1LAP
- TGF beta1LAP