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Transforming Growth Factor beta

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Year introduced: 1991

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Tree Number(s): D12.644.276.374.687, D12.644.276.954.775, D12.776.467.374.687, D12.776.467.942.775, D23.529.374.687, D23.529.942.775

MeSH Unique ID: D016212

Entry Terms:

  • Milk Growth Factor
  • Factor, Milk Growth
  • Growth Factor, Milk
  • TGF-beta
  • TGFbeta
  • Platelet Transforming Growth Factor
  • Bone-Derived Transforming Growth Factor
  • Bone Derived Transforming Growth Factor

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