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Transducin

A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.

Year introduced: 1989

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Subheadings:

Tree Number(s): D08.811.277.040.330.300.200.800, D12.644.360.360.940, D12.776.157.325.332.940, D12.776.476.375.940, D12.776.543.325.800

MeSH Unique ID: D015293

Registry Number: EC 3.6.5.1

Entry Terms:

  • Transducin G-Protein (Gt)
  • Gt, Transducin G-Protein
  • G-Protein Gt, Transducin
  • Gt, Transducin G Protein
  • Transducin G-Protein Gt
  • G-Protein, Inhibitory Gt
  • G Protein, Inhibitory Gt
  • Gt G-Protein, Inhibitory
  • Inhibitory Gt G-Protein
  • gamma-Transducin
  • gamma Transducin
  • Transducin, gamma Subunit
  • gamma Subunit Transducin
  • beta-Transducin
  • beta Transducin
  • Transducin, beta Subunit
  • beta Subunit Transducin
  • alpha-Transducin
  • alpha Transducin
  • Transducin, alpha Subunit
  • alpha Subunit Transducin

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