Tissue Inhibitor of Metalloproteinases

A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.

Year introduced: 1998

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Tree Number(s): D12.776.815.875

MeSH Unique ID: D019714

Entry Terms:

• Metalloproteinases Tissue Inhibitor
• Tissue Inhibitor of Metalloproteinase
• Metalloproteinase Tissue Inhibitor
• TIMP Proteins
• Proteins, TIMP

Previous Indexing:

• Enzyme Inhibitors (1989-1997)
• Glycoproteins (1980-1990)

Pharmacologic Action:

• Matrix Metalloproteinase Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Proteinase Inhibitory Proteins, Secretory
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-1
Tissue Inhibitor of Metalloproteinase-2
Tissue Inhibitor of Metalloproteinase-3
Tissue Inhibitor of Metalloproteinase-4