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Tissue Inhibitor of Metalloproteinase-2

A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.

Year introduced: 1998

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Tree Number(s): D12.776.645.875.500

MeSH Unique ID: D019716

Registry Number: 127497-59-0

Entry Terms:

  • Metalloproteinase-2 Tissue Inhibitor
  • Tissue Inhibitor of Metalloproteinase 2
  • TIMP-2

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Pharmacologic Action:

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