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Thalidomide

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

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Subheadings:

Tree Number(s): D02.241.223.805.810.800, D03.383.621.808.800, D03.633.100.513.750.750

MeSH Unique ID: D013792

Registry Number: 4Z8R6ORS6L

Entry Terms:

  • Sedoval
  • Thalomid

Pharmacologic Action:

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