Tetrahydrofolate Dehydrogenase
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Year introduced: 1966
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.682.662.825
MeSH Unique ID: D013762
Registry Number: EC 1.5.1.3
Entry Terms:
- Dehydrogenase, Tetrahydrofolate
- Dihydrofolate Dehydrogenase
- Dehydrogenase, Dihydrofolate
- Dihydrofolate Reductase
- Reductase, Dihydrofolate
- Folic Acid Reductase
- Acid Reductase, Folic
- Reductase, Folic Acid