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Synapsins

A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.

Year introduced: 1992

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Subheadings:

Tree Number(s): D12.776.631.750, D12.776.744.840

MeSH Unique ID: D016704

Entry Terms:

  • Synapsin II
  • Synapsin III
  • Synapsin I

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