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Steroid 21-Hydroxylase

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Year introduced: 2003 (1978)

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Subheadings:

Tree Number(s): D08.244.453.493.500, D08.244.453.915.760, D08.811.682.690.708.170.463.500, D08.811.682.690.708.170.915.760, D12.776.422.220.453.493.500, D12.776.422.220.453.915.760

MeSH Unique ID: D013255

Registry Number: EC 1.14.14.16

Entry Terms:

  • Cytochrome P-450 21-Hydroxylase
  • Cytochrome P 450 21 Hydroxylase
  • Cytochrome P-450(c-21)
  • Progesterone 21-Hydroxylase
  • Progesterone 21 Hydroxylase
  • Cytochrome P-450 CYP21
  • Cytochrome P 450 CYP21
  • Steroid 21-Monooxygenase
  • Steroid 21 Monooxygenase
  • Cytochrome P450c21
  • Cytochrome P-450 c21
  • Cytochrome P 450 c21
  • P-450 c21, Cytochrome
  • 21-Hydroxylase
  • 21 Hydroxylase
  • Steroid-21-Hydroxylase
  • Steroid 21 Hydroxylase

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