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Steroid 17-alpha-Hydroxylase

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Year introduced: 2003 (1978)

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Tree Number(s): D08.244.453.487.500, D08.244.453.915.748, D08.811.682.690.708.170.444.500, D08.811.682.690.708.170.915.748, D12.776.422.220.453.487.500, D12.776.422.220.453.915.748

MeSH Unique ID: D013254

Registry Number: EC 1.14.14.19

Entry Terms:

  • 17-alpha-Hydroxylase, Steroid
  • Steroid 17 alpha-Hydroxylase
  • 17 alpha-Hydroxylase, Steroid
  • Steroid 17 alpha Hydroxylase
  • Steroid-17-Hydroxylase
  • Steroid 17 Hydroxylase
  • Steroid 17-Hydroxylase
  • 17-Hydroxylase, Steroid
  • Steroid 17-Monooxygenase
  • 17-Monooxygenase, Steroid
  • Steroid 17 Monooxygenase
  • 17,20-Desmolase
  • 17,20 Desmolase
  • 17,20-Lyase
  • 17,20 Lyase
  • Cytochrome P450(17 alpha)
  • Steroid 17 alpha-Monooxygenase
  • 17 alpha-Monooxygenase, Steroid
  • Steroid 17 alpha Monooxygenase
  • alpha-Monooxygenase, Steroid 17
  • CYP17
  • 17 alpha-Hydroxylase
  • 17 alpha Hydroxylase
  • P450(c17)
  • Cytochrome P-450(17-alpha)
  • 17 alpha-Hydroxylase Cytochrome P-450
  • 17 alpha Hydroxylase Cytochrome P 450
  • Cytochrome P-450(17 alpha)
  • 17 alpha-Hydroxyprogesterone Aldolase
  • 17 alpha Hydroxyprogesterone Aldolase
  • Aldolase, 17 alpha-Hydroxyprogesterone
  • alpha-Hydroxyprogesterone Aldolase, 17
  • Hydroxyprogesterone Aldolase
  • Aldolase, Hydroxyprogesterone

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