Sirolimus

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Year introduced: 1999

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Tree Number(s): D02.540.505.760

MeSH Unique ID: D020123

Registry Number: W36ZG6FT64

Entry Terms:

• Rapamycin
• Rapamune
• AY 22-989
• AY 22989
• AY 22 989
• I-2190A
• I2190A
• I 2190A

Previous Indexing:

• Polyenes (1976-1998)

Pharmacologic Action:

• Anti-Bacterial Agents
• Antibiotics, Antineoplastic
• Antifungal Agents
• Immunosuppressive Agents

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Lactones
Macrolides
Sirolimus
Everolimus