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A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Year introduced: 1999

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Tree Number(s): D02.540.505.760

MeSH Unique ID: D020123

Registry Number: W36ZG6FT64

Entry Terms:

  • Rapamycin
  • I-2190A
  • I 2190A
  • I2190A
  • AY 22-989
  • AY 22 989
  • AY 22989
  • Rapamune

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